Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Specially adapted for ruminant animal
Patent
1987-11-16
1990-05-15
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Specially adapted for ruminant animal
424439, 424440, 424441, A23K 118
Patent
active
049256696
DESCRIPTION:
BRIEF SUMMARY
This invention relates to compositions having therapeutic properties, which are particularly useful in veterinary practice.
It is common practice to administer drugs and other therapeutic agents to animals, either to treat infections and other undesirable conditions or to produce and/or maintain good health and other desirable conditions. It has now been discovered that a wide range of compositions for such purposes can be made, by a number of methods which also form aspects of this invention. The compositions of the invention contain the desired therapeutic agent, or agents in association with carrier or substrate substances as explained below. It has also been discovered that known beneficial effects of the carrier substances can be produced in conjunction with the desired effects of the therapeutic agents. Furthermore, the preferred carrier substances have been found to act as slow-release agents and so give improved performance by the therapeutic agent involved.
In accordance with an aspect of this invention, a therapeutic composition comprising at least one veterinary therapeutic agent is characterised in that the composition includes at least one substrate selected from zeolites and pillared clays, with which the therapeutic agent is associated by internal sorption and/or external adsorption. For simplicity, the term "drug" is used below to describe any therapeutic agent suitable for use in accordance with this invention. A preferred feature of the invention is the use, as the therapeutic agent, of at least one anthelmintic agent.
In accordance with another aspect of this invention, a method of manufacture of a therapeutic composition comprising at least one veterinary therapeutic agent is characterised in that the therapeutic agent in solution or vapour form is brought into contact with a substrate selected from zeolites and pillared clays comprising at least one zeolite compound and/or pillared clay, for a time sufficient to allow a significant amount of the agent to become associated by internal sorption and/or external adsorption with the substrate and, if required, the resultant composition is caused or allowed to dry. In appropriate instances, a solution can be contacted with the zeolite compound or other substrate which contains 2 or more drugs which are desired in the resultant composition. Alternatively, a composition containing two or more drugs can be made by contacting the zeolite and/or pillared clay substrate in sequence with a solution of each of the drugs of interest.
Zeolites are hydrated alumino-silicates, having framework structures enclosing cavities and channels, which can contain mobile cations and water molecules. As is known, zeolites can undergo reversible ion exchange and water loss reactions and they also have molecular sieve properties. The general formula of zeolites, both as natural and synthetic forms, is as follows: respectively, n can have any value from 1 upwards and m can have any integral or fractional value in the range from 0 to 5. Modern synthetic techniques allow either or both of the Al and Si atoms to be replaced by atoms of other elements in the zeolite framework. Replacement can also be effected by altering existing zeolite substances. Elements introduced in this way include P, for Si, as in AlPO compounds and many others, such as Be, Zn, Sn, Fe, B, Ga, Ge, Zr and Ti. Another variant involves the substitution of M.sup.III, i.e. trivalent ions, for at least part of the M.sup.I and M.sup.II in the general formula. M.sup.I, N.sup.II and M.sup.III can be selected from any desired inorganic and organic cations. Thus the chemical modification of zeolites has previously been concerned with ion replacement or the physio-chemical attachment of ions or small molecules, such as water.
Clays which have been treated in known manner so that the individual platelets or other particles are more widely spaced, namely pillared clays, are also useful as substrates for the veterinary compositions of the invention.
It has now surprisingly been discovered that certain drug molec
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Dyer Alan
Wells Phyllis D.
Williams Craig D.
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