Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2005-01-25
2005-01-25
Smith, Lynette R. F. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S184100, C424S185100, C424S263100, C530S350000, C435S069300, C435S252300, C435S320100, C536S023100, C536S023200, C536S023700
Reexamination Certificate
active
06846487
ABSTRACT:
The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated byLawsonia intracellularisor similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived fromLawsonia intracellularis, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity againstLawsonia intracellularisand related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detectingLawsonia intracellularisor similar or otherwise related microorganisms.
REFERENCES:
patent: WO 9639629 (1996-12-01), None
patent: WO 9720040 (1997-06-01), None
Rudinger et al, in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976, p. 6.*
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Ellis, R.W. (Chapter 29 of “Vaccines” Plotkin, 5.A. et al. (eds) published by W. B. 5aunders company (Philadelphia) in 1988, especially p. 571.*
Boye et al.,Specific Detection of Lawsonia intracellularis in Porcine Proliferation Enteropathy Infered from Fluorecent rRNA In Situ Hybridization, Vet Pathol 35:153-156 (1998).
Good Robert Trygve
King Kendall Wayne
Rosey Everett Lee
Strugnell Richard Anthony
Agriculture Victoria Services Pty Ltd.
Austrailian Pork Limited
Baskar Padma
Kohn Kenneth I.
Kohn & Associates PLLC
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