Therapeutic compositions comprising a CD4 peptide and methods of

Details Therapeutic compositions comprising a CD4 peptide and methods of Therapeutic compositions comprising a CD4 peptide and methods of

1993-12-21

1998-06-16

Furman, Keith C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

4241851, 4241931, 4241941, 514 8, 514 13, 5303917, 5303919, 530402, A61K 3810, A61K 3816

Patent

active

057670722

ABSTRACT:
Disclosed are methods and compositions for the treatment of HIV infections through the specific elimination of cells which express HIV env determinants such as gp120. The compositions of the invention include toxin conjugates composed of a CD4 derived gp120 binding ligand conjugated to a toxin A chain moiety such as ricin A chain or deglycosylated ricin A chain. Where a therapeutic composition is desired, the conjugates are formed by means of a cross linker which includes a disulfide bond. Disulfide linkages are not crucial where non-therapeutic uses, such as antibody generation, is intended. In preferred aspects of the invention, conjugates incorporating shorter CD4 peptides, such as those incorporating amino acids 41-57 or 41-84 of CD4, are disclosed. Therapeutic amounts of conjugates composed of soluble CD4 or a CD4 peptide cross-linked to deglycosylated A chain by means of as SMPT linker is administered to an HIV infected patient so as to specifically eliminate HIV infected cells without exerting significant toxicity against uninfected or class II cells.

REFERENCES:
patent: 4935465 (1990-06-01), Garman et al.
patent: 5116944 (1992-05-01), Sivam et al.
patent: 5206353 (1993-04-01), Berger et al.
Schniffman et al. (1988) J. Immunol. 141, 4181-4186.
Ghetie et al. (1991) Proc. Natl. Acad. Sci. 88, 5690-5693.
"HIV-Infected Cells Are Killed by rCD4-Ricin A Chain", Science, Nov. 25, 1988, vol. 242, pp. 1166-1168.
"Studies are Exploring Potential of Soluble CD4 Therapy for HIV", Exchange, published by NIAID, May/Jun., 1989, pp. 5-9.

Affiliated with

Also associated with

Rating

Therapeutic compositions comprising a CD4 peptide and methods of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic compositions comprising a CD4 peptide and methods of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic compositions comprising a CD4 peptide and methods of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1726034