Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-12-08
2000-05-23
Travers, Russell
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514574, A01N 3700
Patent
active
060666706
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The invention relates to admixture compositions of short chain organic fatty acids which have biological effects. For example, they are useful in the treatment of numerous pathologies that affect mammals. The invention also relates to methods of treatment of such pathologies, wherein appropriate therapeutically effective amounts of the compositions are administered.
BACKGROUND OF THE INVENTION
A wide variety of carboxylic acid containing compositions are biologically active, and several short chain organic acids which are naturally occurring acids have previously been implicated in the treatment of various pathological conditions. For example, Nordman, U.S. Pat. No. 3,291,689, discloses the treatment of hepatic ammonia intoxication with a mixture of L-arginine and malic acid. U.S. Pat. No. 3,718,664 discloses the use of thioctic acid derivatives in the treatment of acidosis.
Sloan, U.S. Pat. No. 4,381,307, discloses soft tertiary amine ester derivatives that have biological effects, while U.S. Pat. No. 4,760,078 discloses a 1,2, dithiol-3-thione derivative that has an immunomodulating effect.
Rubenstein, U.S. Pat. No. 4,971,760, discloses the sterilization of blood, blood constituents, and transplant tissues with a disinfectant that includes lactic acid and sodium chlorite. Naphtholic acid derivatives were discovered to be useful in enhancing oxygen availability to mammalian tissue by Suh et al., U.S. Pat. No. 5,015,663.
Hoffiler et al., U.S. Pat. No. 5,043,357, disclose a virucidal agent that is predominantly comprised of ethanol and/or alcohol but which includes a minor amount of a short chain organic acid. Further, U.S. Pat. No. 5,093,140 discloses an aqueous bactericide that contains organic acids. This solution is used in the scalding or washing stages of meat dressing. Kross et al., U.S. Pat. No. 5,100,652 disclose an oral disinfectant that contains organic acids. See also Comroe et al., The Lung, 1955 Yearbook of Medical Publications Inc., Chptr. 4; John West, Respiratory Physiology, The Williams & Wilkins Co., Chptr. 6; Hypoxia, Metabolic Acidosis and Circulation, ARTCF . . . Oxford; Arnold et al, "Excessive Intracellular Acidosis of Skeletal Muscle on Exercise in a Patient with a Post-Viral Exhaustion/Fatigue Syndrome" The Lancet: Jun. 23, 1984; Schweckendiek, W., "Heilung von Psoraiasis vulgaris", Med. SschS, 13:103-4, 1959; G. E. Abraham et al., "Rationale for the Use of Magnesium and Malic Acid", Journal of Nutritional Medicine, 3:49-49 (1992); Kuroda, Z. and Akano, M., "Antitumor and Anti-intoxication Activities of Fumaric Acid in Cultured Cells", Gann, 727:77-782 (1981); Chemical Abstracts 98945Y, 116, March 1992 "Antifungal Activity of Fumarates in Mice Infected with C. Albicans"; Bauer et al., "Clinishe Wochenschrift 1991 69(2), pp. 722-4; for further details of several pathological processes which are susceptible to treatment according to the present invention.
It has now been discovered that admixtures of specific short chain organic acids have broad therapeutic effects.
SUMMARY OF THE INVENTION
According to the present invention, there is provided a composition which comprises an admixture of sorbic acid, aconitic acid, malic acid, fumaric acid, crotonic acid, and optionally aconitic acid.
Further contemplated by the present invention are methods for treating various pathological conditions such as viral infections including, but not limited to, cytomegalovirus and hepatitis infections; acidosis; tumors; and bacterial and fungal infections, by administering various therapeutically effective amounts of the admixture described above.
DETAILED DESCRIPTION OF THE INVENTION
Organic acids are a large group of compounds, many of which can be derived from proteins, carbohydrates, and fats. Although many occur naturally, many can be synthetically produced without great difficulty.
Sorbic acid is a crystalline diolefinic acid having the formula C.sub.6 H.sub.8 O.sub.2. Typically, it is used as mold and yeast inhibitor; a fungistatic agent for foods, especially chee
REFERENCES:
patent: 4828912 (1989-05-01), Hossain et al.
Poli et al 91 CA 187263g 1979.
Stein Mitchell A.
Travers Russell
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