Therapeutic compositions

Details Therapeutic compositions Therapeutic compositions

1986-10-31

1989-02-21

Lusignan, Michael

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424494, 514570, A61K 946

Patent

active

048063584

ABSTRACT:
Novel pharmaceutical powder and tablet compositions comprise ibuprofen or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable effervescent couple that produces carbon dioxide in the presence of water, a pharmaceutically acceptable surfactant and a pharmaceutically acceptable water-insoluble hydrophilic polymer. Preferred hydrophilic polymers are microcrystalline cellulose and croscarmellose sodium.
Especially preferred are such compositions which have a saccharide dispersed therein. The incorporation of the saccharide, for example sucrose, lactose, dextrose or sorbitol, enhances the stability of the compositions.

REFERENCES:
patent: 4289751 (1981-09-01), Windheuser
patent: 4414198 (1983-11-01), Michaelson
patent: 4678661 (1987-07-01), Gergely et al.
patent: 4687662 (1987-08-01), Schobel
patent: 4689218 (1987-08-01), Gazzaniga et al.
patent: 4701470 (1987-10-01), Heckler
Scrip.
Chem. Abs., vol. 74 (1971) 76639z.
Derwent 87-144381/21; 86-125895.

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