Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1989-05-15
1991-02-26
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514352, 514438, 514660, A61K 3113, A61K 3144, A61K 3138
Patent
active
049962361
ABSTRACT:
A pharmaceutical composition for the treatment of hyperammonemia which comprises a valiolamine compound of the formula ##STR1## wherein A means an acyclic hydrocarbon group of 1 to 10 carbon atoms which may optionally be substituted by hydroxy, phenoxy, thienyl, furyl, pyridyl, chclohexyl or optionally substituted phenyl; a 5- or 6-membered cyclic hydrocarbon group which may optionally be substituted by hydroxy, hydroxymethyl, methyl or amino; or a saccharide residue or a pharmaceutically acceptable salt thereof, the use of said valiolamine compound of the formula [I]0 or a pharmaceutically acceptable salt thereof in the preparation of a medicine for the treatment of hyperammonemia, and a method for the treatment of hyperammonemia which comprises administrating a valiolamine compound of the formula [I] or a pharmaceutically acceptable salt thereof.
REFERENCES:
Therapeiwoche, vol. 34, No. 17, 1984, G. Braun Lerlag Zeitschriften, Karlsruhe, DE: D. Muting: "Acarbose bei der Behandlung von Diabetiken mit Gleichzeitiger Leberzirrhose", pp. 2566-2572.
Drugs of the Future, vol. 11, No. 9, 1986, pp. 729-731.
J. Med. Chem., No. 29, 1986, American Chemical Society; S. Horii et al.: "Synthesis and Alpha-D-Glucosidase Inhibitory Activity of N-substituted Valioalmine Derivatives as Potential Oral Antidiabetic Agents", pp. 1038-1046.
Jpn. J. Gastroenterologie, vol. 84, No. 8, 1987, pp. 1639-1644.
The Journal of Antibiotics, vol. 37, No. 11, Nov. 1984, Y. Kameda et al.: "Valiolamine, a New Alpha-Flucosidase Inhibiting Aminocyclitol Produced by Streptomyces hygroscopicus", pp. 1301-1307.
Chem Abst, 108:68718u, (1988), Yoshiaki et al.
Chem Abst, 104:207548w, (1986), Satoshi et al.
Dtsch. Med. Worchenschr. 108, No. 4, 157 (1983).
Esquivel Misael U.
Nakamura Nobuto
Satoh Hiroshi
Fay Zohreh A.
Friedman Stanley J.
Takeda Chemical Industries Ltd.
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