Therapeutic composition containing antibodies to soluble polypep

Details Therapeutic composition containing antibodies to soluble polypep Therapeutic composition containing antibodies to soluble polypep

1998-04-13

2000-11-07

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

4241391, 4241431, 4241521, 5303872, 5303879, 5303887, 53038873, 5303896, 5303913, A61K 5100, A61K 39395, C07K 1628

Patent

active

061432733

ABSTRACT:
Soluble polypeptide fraction consisting of all or part of one at least one of the four immunoglobulin-type extracellular LAG-3 protein domains (amino acids 1-159, 160-230, 240-330 and 331-412 of the SEQ ID NO:1 sequence) or consisting of one peptide sequence derived from these domains by replacement, addition or deletion of one or more amino acids. The fraction of the invention has a specificity at least equal to that of LAG-3 in relation to its ligand.

REFERENCES:
Biaxeras, E. et al. J. Exp. Med. 176(2):327-337, Aug. 1992.
Triebel, F. et al. J. Exp. Med. 171(5):1393-1405, May 1990.
Huard, B. et al. Intl. Con. Immunol. (Abstracts) p. 281, Aug. 1992.
Eilat, D. et al. Proc. Nat. Acad. Sci. (USA). 89(15):6871-6875, Aug. 1992.
DeSantes, K. et al. Cancer Research. 52:1916-1923, Apr. 1992.
Taetle, R. et al. J. Natl. Cancer Inst. 80(13):1053-1059, Sep. 1988.

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