Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Multienzyme complexes or mixtures of enzymes
Reexamination Certificate
2002-12-24
2008-09-30
Naff, David M. (Department: 1657)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Multienzyme complexes or mixtures of enzymes
C424S094640, C424S094670, C435S177000, C435S178000, C435S180000
Reexamination Certificate
active
07429377
ABSTRACT:
A pharmaceutical composition having thrombolytic, anti-inflammatory and cytoprotective properties is described. The composition contains active proteases attached to a gel or to a mixture of a gel with a water-soluble polymer, said attachment being achieved with the help of radiation, preferably with the help of gamma-radiation or a flow of accelerated electrons. As the proteases the composition contains proteases which are stable at a temperature of up to 70° C., preferably at 30-40° C., for instance such as subtilysine, trypsin, chemotrypsin, papain or streptokinase. The gel is preferably polyethylene glycol gel, dextran gel, or polyglycane gel, and the water-soluble polymer is polyethylene glycol, polyvinyl alcohol, dextran or polyglycane. The method of preparing said composition and its use are also disclosed. The composition has a broad range of application, and can be used in cardiology, nephrology, surgery, rheumatology, gynecology and gastroenterology.
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English Translation of Claims of RU 2137835 Dated Sep. 20, 1999.
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Artamonov Andrei Vladimirovich
Grishin Oleg Vitalievich
Troitsky Alexandr Vasilievich
Vereschagin Evgeny Ivanovich
Ladas and Parry LLP
Naff David M.
Zakrytoe Aktsionernoe Obschestvo “Aksis”
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