Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from arthropod
Patent
1992-10-11
2000-11-28
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from arthropod
514731, A61K 3564, A61K 3105
Patent
active
061532266
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a novel therapeutic composition containing a phenol component and propolis. This composition is userful as an antiviral agent, in general against lipid capsid viruses (abbreviated to LCV's) and in particular against herpes viruses and their analogs which form part of the LCV group.
PRIOR ART
It is known that phenols have already been recommended in therapeutics as anti-infective agents on account of their bacteriostatic or mycostatic properties.
Among these phenols, it is known, in particular from French patent FR-B-2 507 891, the article by W. SNIPES et al., Sciences, 187, pages 64-65 (1975), and the articles by W. SNIPES et al. entitled "Hydrophobic Alcohols and Di-tert-butyl Phenols as Antiviral Agents" and published in the work "Symposium on the Pharmacological Effects of Lipids", pages 63-73, The American Oil Chemists' Society, Champaign, Illinois (1978), that the BHT's of formula I below, namely the 4-alkyl-2,6-di-t-butylphenols in which the alkyl group in the 4-position contains a linear hydrocarbon chain of 1 to 12 carbon atoms, have inhibitory and/or virucidal effects on LCV's and especially herpes viruses. According to the second article by W. SNIPES et al. cited above, it is known that the antiherpetic activity depends on the nature of the 4-alkyl group of the BHT and that the BHT which has an n-butyl radical in the 4-position is virtually the only one active against HSV.sub.2.
It is further known that propolis is a gummy substance recovered from beehives. More precisely, it is a substance which the bees collect from certain plants, especially the scales of poplar and alder buds, amass and use for filling in cracks in the beehives, fixing the honeycombs and glazing the walls. In the field of apiculture, propolis is known to be the antibiotic or disinfectant in the beehive, preventing bacteria and molds from proliferating.
Crude propolis generally contains resins and balsamic substances (approximately 55-50% by weight), beeswax (approximately 30-35% by weight), ethereal oils (approximately 10% by weight) and pollens (approximately 5% by weight); see especially EP-A-0 061 508 (page 2, lines 1-28), EP-A-0 109 993 (page 1, lines 24-26) and E. M. SCHNEIDEWIND et al., Die Pharmazie 34, 103 (1978).
The antiviral properties of propolis extracted from beehives and purified, against herpes viruses (especially HSV.sub.1 and HSV.sub.2) and influenza viruses (especially IV.sub.A), are known especially from EP-A-0 061 508 (page 3, lines 6-7) and EP-A-0 109 993 (page 2, lines 3-8; page 10, lines 7-11; and page 11, lines 1-4) cited above, on the other hand, and EP-A-0 310 757 (page 3, lines 31-32), on the other.
Furthermore, a technique for the treatment of viral infections is known from abstract n.degree. 83-762896 in DATABASE WPI/L of Derwent Publications Ltd, which relates to document R0-A-81 340, according to which technique (a) an alcoholic solution of propolis is administered orally and, simultaneously, (b) the locally affected areas are coated with an alcoholic propolis composition which may contain a phenol component (in the case in question, salicyclic acid as an anti-inflammatory agent) and/or vitamins; also, an antiherpes composition comprising propolis (one part by weight), phenol (0.5 part by weight) and menthol (one part by weight) is known from Chemical Abstracts CA 103, 220838q, which relates to document R0-A-86 003.
Now, it so happens that these last two documents neither describe nor suggest the synergistic composition of the invention, in which the weight ratio phenol component/propolis is between 100/1 and 650/1.
AIM OF THE INVENTION
According to the invention, a novel technical solution is recommended which uses an antiviral composition comprising a synergistic mixture of a phenol component and propolis in association.
This novel technical solution is advantageous in the sense that it makes it possible especially to reduce the practical doses previously recommended in the antiviral indications for the phenol component and propol
REFERENCES:
Weuffen et al 73 CA: 128140a 1970.
Glinnik et al 95 CA: 144148p 1981.
Sheuvhenko et al 82 CA: 68322e 1975.
Meresta et al 109 CA: 351198s 1988.
Snipes et al 92 CA: 221x 1980.
Vachy 98 CA: 204426b 1983.
Wright 72 CA: 75997a 1970.
Prakash et al 93 CA: 199103j 1980.
Popescu et al 103 CA 220838q 1985.
Anan'ev et al 105 CA: 54144e 1986.
Thiel et al 84 CA: 160055j 1976.
Knight et al 88 CA: 182572k 1978.
Kane et al 109 CA: 47853q 1988.
Database WPI (L)/Derwent, No. 83-762896, & RO, A, 81340 (Colentina Spitalul) 1985.
Chemical Abstracts, vol. 103, No. 26, Dec. 30 1985, (Columbus, OH, US), see p. 359, abstract 220838q, & RO, A 86003 Institutul De Medicina & Farmacie) Jan. 30, 1985.
Chemical Abstracts, vol. 83, No. 17, Oct. 27, 1975, (Columbus, OH, US), A.I. Tikhonov et al.: Phisiochemical and microbiological properties and quantitative determinations of water-soluble.
Amoros Maryvonne
Sauvager Fran.cedilla.oise
Vachy Robert
Cintins Marianne M.
Fileco
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