Therapeutic combination of free-radical scavenger and tumor necr

Details Therapeutic combination of free-radical scavenger and tumor necr Therapeutic combination of free-radical scavenger and tumor necr

1989-08-25

1991-01-15

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 514 2, 514 8, 514885, A61K 3702

Patent

active

049852418

ABSTRACT:
Damage to cells, tissue and other body parts in a mammalian host may be treated by using a lymphokine or cytotoxin in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The lymphokine or cytotoxin is preferably tumor necrosis factor and the biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, and damage caused by radiation therapy, high oxygen tension, and chemotherapy.

REFERENCES:
Das et al., J. Free Radicals in Biology and Medicine, vol. 2, 1986, pp. 183-188.
Arrick et al., J. Clin. Invest., 71(2):258-267 (1983).
Romine and Kessel, Biochem. Pharmacol. (UK) (1986) 35(19) pp. 3323-3326.
Hamilton et al., Biochem. Pharmacol. (Jul. 15, 1985) 34(14):2583-2586.
Ono et al., Br. J. Cancer (UK) (1986) 54:749-754.
Andrews et al., Cancer Res. (Dec. 1985) 45(12 Pt1):6250-6253.
Russo et al., Cancer Res. (Jun. 1986) 46:2845:2848.
Tew et al., Cancer Treatment Rep. (Jun. 1986), 70:715-720.
Russo et al., Int. J. Radiat. Oncol. Biol. Phys. (Aug. 1986), 12:1347-1354.
Dorr et al., Invest. New Drugs (1986) 4:305-313.
Green et al., Cancer Res. (Nov. 1984) 44:5427-5431.
Ozols, Semin. Oncol. (Sep. 1985) 12:7-11.
Ozols et al., Devl. Oncol. (1986) 47:277-293.
Crook et al., Cancer Res. (1986) 46:5035-5038.
Hodgkiss et al., Biochem. Pharmacol. (1985) 34:2175-2178.
Somfai-Relle et al., Biochem. Pharmacol. (1984) 33:485-490.
Neta et al., J. Immunol. (1986) 136:2483-2485.
Palladino et al., Clin. Res. (1986) 34:502.
Palladino et al., Ped. Res. (1986) 20:302.
Petkau, Acta. Physiol. Scand. Suppl. (1980) 492:81-90.
Tomasz, Chem. Biol. Interact. (1976) 13:89-97.
DiGuiseppi and Fridovish, CRC Crit. Rev. Toxicol. (1984) 12:315-342.
Slater, Biochem. J. (1984) 222:1-15.
Bus and Gibson in Rev. Biochem. Toxicol., eds. Hodgson et al., (Elsevier, North Holland, 1979) pp. 125-149.
Badwey and Karnovsky, Ann. Rev. Biochem. (1980) 49:695-726.
Moody and Hassan, Proc. Natl. Acad. Sci. (USA) (1982) 79:2855-2859.
Lesko et al., Biochemistry (1980) 19:3023-3028.
Cerutti et al., in Genes and Proteins in Oncogenesis (Academic Press, NY, 1983) pp. 55-67.
Fridovich, Science (1978) 201:875-880.
Meister and Anderson, Ann. Rev. Biochem. (1983) 52:711-760.
Ames et al., Proc. Natl. Acad. Sci. (USA) (1981) 78:6858-6862.
Adams et al., J. Pharmacol. Exp. Ther. (1983) 227:749-754.
Minchinton et al., Int. J. Radiation Oncology Biol. Phys. (1984) 10:1261-1264.
Morin and Ballet, Allergol. Immunopathol. (1982) 10:109-114.
Palladino et al., Int. J. Radiat. Biol. (1982) 41:183-191.
Svedersky, Int. J. of Immunopharm., vol. 7 (3) 330.
Marcus et al., Cancer Research, 47:4208-4212 (1987).
Bachwich et al., Biochem Biophy Res Comm 136(1) 1986, pp. 94-101.
Kawakami et al., Biochem Biophy Res Comm 141(2) 1986, pp. 482-487.
Almqvist et al., Circulatory Shock 13, 1984, pp. 227-232.
Alexander et al., Cancer Res. 47, 1987, pp. 2403-2406, CA vol. 107, #32744q.
Kull et al., Cancer Res 41, 1981, pp. 4885-4890.
Ballwell et al., Cancer Res 46, 1986, pp. 3990-3993.
Ruff et al., Inf and Inmunity 31(1), pp. 380-385, 1981.
Kunkel et al., Biochem Res Comm 137(1) 1986, pp. 404-410.

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