Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-01-21
2008-05-20
Weber, Jon (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008100, C514S011400, C514S023000, C514S049000, C514S383000, C530S317000, C435S068100, C435S231000
Reexamination Certificate
active
07375081
ABSTRACT:
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention relates to antifungal combination use of azoles such as fluconazole, voriconazole, itraconazole, ketoconazole, miconazole, ER 30346 and SCH 56592; polyenes such as amphotericin B, nystatin, liposomal and lipid forms thereof such as Abelcet, AmBisome and Amphocil; purine or pyrimidine nucleotide inhibitors such as flucytosine; or polyoxins such as nikkomycins, in particular nikkomycin Z or nikkomycin X; other chitin inhibitors; elongation factor inhibitors such as sordarin and analogs thereof; mannan inhibitors such as predamycin, bactericidal/permeability-inducing (BPI) protein products such as XMP.97 or XMP.127; or complex carbohydrate antifungal agents such as CAN-296; with a lipopeptide compound [I] as described herein.
REFERENCES:
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S. P. Franzot, et al., Antimicrobial Agents and Chemotherapy, vol. 41, No. 2, pp. 331-336, “Pneumocandin L-743,872 Enhances the Activities of Amphotericin B and Fluconazole Against Cryptococcus Neoformans in Vitro”, Feb. 1, 1997.
K. Bartizal, et al., Antimocrobial Agents and Chemotherapy, vol. 39, No. 5, pp. 1070-1076, “In Vitro Evaluation of The Pneumocandin Antifungal Agent L-733560, A New Water-Soluble Hybrid of L-705589 and L-731373”, May 1, 1995.
Ikeda Fumiaki
Matsumoto Satoru
Otomo Kazumi
Wakai Yoshimi
Astellas Pharma Inc.
Mohamed Abdel A
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Weber Jon
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