Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-04-24
1996-06-25
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514907, A61K 31135
Patent
active
055300294
ABSTRACT:
The present invention relates to therapeutic uses of clenbuterol in humans and animals. The uses include retarding or reversing muscle disease such as muscular dystrophy, alleviating or reversing peripheral nervous system disease, and alleviating or reversing central nervous system disease.
REFERENCES:
patent: 3536712 (1970-10-01), Keck et al.
patent: 3574211 (1971-04-01), Keck et al.
patent: 3818011 (1974-06-01), Challier et al.
patent: 3925475 (1975-12-01), Horrom
patent: 3950393 (1976-04-01), Keck et al.
patent: 4119710 (1978-10-01), Engelhardt et al.
patent: 4214001 (1980-07-01), Engelhardt et al.
patent: 4228187 (1980-10-01), Lambelin et al.
patent: 4276304 (1981-06-01), Ikezaki et al.
patent: 4355045 (1982-10-01), Preston et al.
patent: 4404222 (1983-09-01), Baker et al.
patent: 4407819 (1983-10-01), Kiernan et al.
patent: 4415564 (1983-11-01), Gamba et al.
patent: 4432995 (1984-02-01), Kiernan et al.
patent: 4761421 (1988-08-01), Muir
patent: 4847302 (1989-07-01), Muir
"The Effect of a Growth Promoting Drug, Clenbuterol, on Fibre Frequency and Area in Hind Limb Muscles from Young Male Rats," by C. A. Maltin M. I. Delday, and P. J. Reeds, Bioscience Reports, vol. 6, No. 3, pp. 293-299 (Jun. 2, 1986).
"Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol," by C. A. Maltin, P. J. Reeds, M. I. Delday, S. M. Hay, F. G. Smith and G. E. Lobley, Bioscience Reports, vol. 6, No. 9, pp. 811-818 (Dec. 17, 1986).
"Propranolol Apparently Separates the Physical and Compositional Characteristics of Muscle Growth Induced by Clenbuterol," by C. A. Maltin, M. I. Delday, S. M. Hay, F. G. Smith and P. J. Reeds, Bioscience Reports, vol. 7, No. 1, pp. 51-57 (Jun. 19, 1987).
"The Effect of the Anabolic Agent, Clenbuterol, on Overloaded Rat Skeletal Muscle," by C. A. Maltin, M. I. Delday, S. M. Hay, F. G. Smith, G. E. Lobley and P. J. Reeds, Bioscience Reports, vol. 7, No. 2, pp. 143-149 (Aug. 3, 1987).
"The Effect of .beta.-Agonists and Antagonists on Muscle Growth and Body Composition of Young Rats (Rattus SP.)," by P. J. Reeds, S. M. Hay, P. M. Dorward and R. M. Palmer, Comp. Biochem. Physiol., vol. 89C, No. 2, pp. 337-341, (1988).
"Clenbuterol, A Beta Agonist, Induces Growth in Innervated and Denervated Rat Soleus Muscle via Apparently Different Mechanisms," by C. A. Maltin, S. M. Hay, M. I. Delday, F. G. Smith, G. E. Lobley and P. J. Reeds, Bioscience Reports, vol. 7, No. 6, pp. 525-532, (1987).
EPO Search Report, EP Application 88308402.2 24 Jun. 1991.
"Clenbuterol, a .beta..sub.2 -agonist, retards atrophy in denervated muscles," by R. J. Zeman, R. Ludemann, and J. D. Etlinger, American Journal of Physiology; vol. 252, pp. E152-E155 (1987).
"Modification of body composition by clenbuterol in normal and dystrophic (mdx) mice," by N. J. Rothwell and M. J. Stock, Bioscience Reports 5, pp. 755-760 (1985).
"Chronic effects of .beta..sub.2 -adrenergic agonists on body composition and protein synthesis in the rat," by P. W. Emery, N. J. Rothwell, M. J. Stock, and P. D. Winter, Bioscience Reports 4, pp. 83-91 (1984).
Chemical Abstracts, vol. 102, pp. 596, (1985).
"Metabolism and Nutrition--A Repartitioning Agent to Improve Performance and Carcass Composition of Broilers," by R. H. Dalrymple, P. K. Baker, P. E. Gingher, D. L. Ingle, J. M. Pensack, and C. A. Ricks, Poultry Science 63, pp. 2376-2383 (1984).
Chemical Abstracts, vol. 104 (1986) (2 pages, page no. unreadable).
"Effects of a .beta.-agonist (clenbuterol) on growth, carcass composition, protein and energy metabolism of veal calves," by P. E. V. Williams, L. Pagliani, G. M. Innes, K. Pennie, C. I. Harris and P. Garthwaite, British Journal of Nutrition, 57, pp. 417-428 (1987).
"Stimulation of muscle growth by clenbuterol: lack of effect on muscle protein biosynthesis," by P. J. Reeds, S. M. Hay, P. M. Dorwood, and R. M. Palmer, British Journal of Nutrition, 56, pp. 249-258, (1986).
EPO Search Report, European Application 95101362.2, May 15, 1995.
D. H. Bermann, D. E. Hogue, "Effect of cimaterol and fishmeal on body composition and skeletal muscle growth in lambs," Chemical Abstracts, vol. 106, pp. 546 (1987), abstract #'s 49102f and 49103g.
".beta..sub.1 Selective Adrenoceptor Antagonists. I. Synthesis and .beta.-Adremergoc Blocking Activity of a Series of Binary (Aryloxy) propanolamines," by R. W. Kierstead, A. Faranone, F. Mennona, J. Mullin, R. W. Guthrie, H. Crowley, B. Simko and L. C. Blaber, J. Med. Chem., pp. 1561-1569, (1983).
"Cimeratol-Induced Muscle Hypertrophy and Altered Endocrine Status in Lambs" by D. H. Beermann, W. R. Butler, D. E. Hogue, V. K. Fishell, R. H. Dalrymple, C. A. Ricks, and S. G. Scanes. J. Anim. Sci., 1987, vol. 65, pp. 1514-1524.
"Side Effects of Clenbuterol As a Repartitioning Agent" by J. M. Brockway, J. C. MacRae, and P. E. V. Williams. Paper and Articles, The Veterinary Record, Apr. 18, 1987. pp. 381-383.
"Effects of Cimaterol and Fishmeal on Performance, Carcass Characteristics and Skeletal Muscle Growth in Lambs" by D. H. Beermann, D. E. Hogue, V. K. Fishell, R. H. Dalrymple, and C. A. Hicks. J. Anim. Sci., 1986, vol. 62, pp. 370-380.
"Use of .beta.-Adrenergic Agonist to Alter Muscle and Fat Deposition in Lambs" by P. K. Baker, R. H. Dalrymple, D. L. Ingle, and C. A. Ricks. Journal of Animal Science, vol. 59, No. 5, 1984. pp. 1256-1261.
"A Short Review and Recent New Data on the Effects of Treating Domestic Livestock With Beta-Agonists" by P. E. V. Williams, 1987.
"Muscle Metabolism and Real-Time Ultrasound Measurement on Muscle and Subcutaneous Adipose Tissue Growth in Lambs Fed Diets Containing a Beta-Agonist" by P. L. Hamby, J. R. Stouffer, and S. B. Smith. J. Anim. Sci., 1986. Vol. 63, pp. 1410-1417.
"The Use of .beta. Agonists As a Means of Altering Body Composition in Livestock Species" by P. E. V. Williams. Nutrition Abstracts and Reviews (Series B), C.A.B. International, Aug., 1987. vol. 57, No. 8, pp. 453-464.
"Selectivity of Clenbuterol (NAB-365) in Guinea-Pig Isolated Tissue Containing .beta.-Adrenoceptors" by S. R. O'Donnell. Arch. int. Pharmacodyn. 224, pp. 190-198 (1976).
"The in vitro Actions of Clenbuterol (NAB-365) on Bovine Pulmonary Vein and Artery" by K. B. Mirbahar and P. Eyre. J. Vet. Pharmacol. Therap. 8, pp. 202-204, 1985.
"Tolerance to or Facilitation of Pharmacological Effects Induced by Chronic Treatment With the Beta-adrenergic Stimulant Clenbuterol" by H. Frances, B. Diquet, P. Goldschmidt, and P. Simon. J. Neutral Transmission 62, pp. 65-76 (1985).
"Clenbuterol, a Central .beta.-Androceptor Agonists" by H. Hall, M. Sallermark, and S. Ross. Letter to Editor, Acta pharmacol et toxicol., 1980, 47, pp. 159-160.
"Does a Single Priming Injection of Clenbuterol Alter Behavioral Response to .beta.-Androceptor Agonists and Antagonists in Mice Through a Time-Dependent Process?" by P. Martin, P. Soubrie, and Pierre Simon. European Journal of Pharmacology, 115 (1985), pp. 91-96.
"The Cardiovascular Effects of Intravenous Clenbuterol (NAB 365) and Terbutaline, Two Selective .beta..sub.2 -Adrenoceptors and Agonists" by C. Pasotti and C. Vibelli, Current Therapeutic Research, vol. 25, No. 4, Apr. 1979. pp. 473-480.
"Clenbuterol (`Spiropent`): Long-Acting Bronchodilator" by D. Wheatley, M.D., E. R. C. Psych. Current Medical Research and Opinion, vol. 8, No. 2, 1982.
"Acute Bronchodilator Effect of Intravenously Injected Clenbuterol" by P. C. Curti and C. Vibelli. Current Therapeutic Research, vol. 25, No. 4, Apr., 1979. pp. 465-471.
"The Effect on the .beta.-2 Adrenergic Agonist Clenbuterol or Implantation With Oestradiol Plus Trenbolone Acetate on Protein Metabolism in Wether Lambs" by O. Bohorov, P. J. Buttery, H. H. R. D. Correia, and J. B. Soar. British Journal of Nutrition (1987), 57, pp. 99-107.
Hypothesis: "Depressed Protein Synthesis is the Dominant Characteristic of Muscle Wasting and Cachexia" by M. J. Rennie, R. H.T. Edwards, P. W. Emery, D. Halliday, K. Lundholm, and D. J. Millward, Clinical Physiology, vol. 3, pp. 387-389 (1983).
"The Mode of Action of Beta-Agonists as Manipulators of Carcass Composition" by P. J. Buttery and
Cintins Marianne M.
Jarvis William R. A.
The Rowett Research Institute
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