Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-08-02
1996-07-02
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31495
Patent
active
055322395
ABSTRACT:
This invention relates to treatment or prevention of nephrotic syndromes by administration of a derivative of the fluoroquinolone class corresponding to the general formula: ##STR1## in which: R.sub.1 is an alkyl (1 to 4 carbon atoms), fluoroethyl, cyclopropyl, methylamino or difluorophenyl radical, X represents a nitrogen atom or a group .dbd.CRT.sub.7 -- in which R.sub.7 is H, Cl or F or alternatively R.sub.7 forms, with the R.sub.1 radical and the atoms to which they are attached, a six-membered heterocycle substituted by methyl and optionally containing an oxygen or sulphur atom, R.sub.2 is H, or can represent an amino radical, if R.sub.7 is F, and R.sub.3 is H, a 2,8-diazabicyclo[4.3.0]non-8-yl radical or a radical of structure: ##STR2## in which R.sub.4, R.sub.5 and R.sub.6 are identical or different and represent H or methyl, or one of its pharmaceutically acceptable salts.
REFERENCES:
patent: 4448962 (1984-05-01), Irikura et al.
patent: 4499091 (1985-02-01), Wentland et al.
patent: 4668784 (1987-05-01), Mascellani et al.
patent: 4704459 (1987-11-01), Todo et al.
patent: 4795751 (1989-01-01), Matsumoto et al.
The Merck Manual, 14th Edition (1982) pp. 1544-1549.
The Lancet "Perfloxacin as first-line treatment in Nephrotic syndrome", vol. 340: Sep. 19, 1992, A. Pruna et al.
Le Quotidien du Medecin "un role inattendu pour un antibiotique: le traitement du syndrome nephrotique" Sep. 21, 1992, Dr. De Viel.
"Conventional Therapy for Idiopathic Nephrotic Syndrome in Children", J. Brodehl, Clinical Nephrology, vol. 35, Suppl. 1, pp. S8-15, 1991.
Assistance Publique - Hopitaux de Paris
Henley III Raymond
LandOfFree
Therapeutic application of fluoroquinolone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutic application of fluoroquinolone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic application of fluoroquinolone derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1506577