Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-04-10
1980-03-18
Rosen, Sam
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424312, 424314, A61K 3122, A61K 3123
Patent
active
041940067
ABSTRACT:
Certain methods of using acyl derivatives of d,l-carnitine have been provided in therapy of myocardial anoxia, ischaemia, arrhythmic syndromes and heart failure in both animals and in man. Acetyl-d,l-carnitine and its pharmaceutically acceptable salts, e.g., the hydrochloride salt, have shown a remarkable improvement in therapy of heart fatigue in animals and humans, and in pathological situations characterized by cardiac rhythm disorders. Other very effective carnitine derivatives are: propionyl d,l-carnitine, butyryl-d,l-carnitine, hydroxybutyryl d,l-carnitine, hexanoyl d,l-carnitine, octanoyl d,l-carnitine, decanoyl d,l-carnitine, palmitoyl d,l-carnitine, stearoyl d,l-carnitine, and acetoacetyl d,l-carnitine.
REFERENCES:
Strack et al., Chem. Abst., vol. 85 (1976), p. 186,608n.
Hosein et al., J. of Pharmacol. and Exptl. Therapeutics, vol. 156 (1967) pp. 565-572.
Grollman, Pharmacology and Therapeutics, sixth edition (1965), pp. 357 & 358.
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