Therapeutic anti-inflammatory and analgesic composition containi

Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Anti-inflammatory or anti-irritant

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424449, A61K 3104, A61K 908

Patent

active

057166099

ABSTRACT:
Therapeutic anti-inflammatory and analgesic pharmaceutical compositions containing nimesulide for use transdermally. The pharmaceutical compositions comprise nimesulide, one or more percutaneous enhancers, one or more gelling agent/thickening agents, one or more vehicles/bases and water. The compositions may also contain one or more surfactants and a neutralizing/pH adjusting agent.

REFERENCES:
patent: 4557934 (1985-12-01), Cooper
patent: 5283261 (1994-02-01), Drago
patent: 5380761 (1995-01-01), Szabo et al.
patent: 5446070 (1995-08-01), Mantelle
Drugs 46 (Suppl 1) 1993, Nimesulide Tolerability in Osteoarthritis, Dreiser, et al. pp. 270-274.
Drugs 46 (Suppl 1) 1993, "A Multicentre Double-Blind Investigation Comparing Nimsulde and Naproxen in the Treatment of Minor Sports Injuries", A. Calligaris, et al., pp. 187-190.
Drugs 46 (Suppl 1) 1993, "The Effect of Nimesulide on Prostanoid Formation", E Magni, pp. 10-14.
Chien Yw, Novel Drug Delivery Systems, Mariel Dekker, New York, 1982, pp. 361-375.

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