Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-10-07
1997-11-04
Campbell, Bruce R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 44, 435238, 935 8, 935 33, C07H 2104
Patent
active
056841477
ABSTRACT:
Disclosed are oligonucleotides having nucleotide sequences that hybridize to at least nucleotides 324 to 348 of a conserved gag region of the HIV-1 genome. These oligonucleotides have about 25 to 30 nucleotides linked by at least one non-phosphodiester internucleotide linkage which render them resistant to nuclease digestion. Also disclosed are therapeutic formulations containing such oligonucleotides and methods of inhibition HIV-1 proliferation and of treating HIV-1 infection in a mammal.
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Agrawal Sudhir
Tang Jin-Yang
Campbell Bruce R.
Hybridon, Inc.
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