Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Reexamination Certificate
2005-04-12
2005-04-12
Nickel, G. (Department: 1642)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
C424S093700, C435S325000
Reexamination Certificate
active
06878371
ABSTRACT:
This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which methods comprise: a) isolating autologous bone marrow-mononuclear cells from the subject; and b) transplanting locally into the diseased or damaged tissue an effective amount of the autologous bone-marrow mononuclear cells, thereby forming new blood vessels in the diseased or damaged tissue. The new blood vessels may be capillaries or collateral vessels in ischemic tissue or any site of angiogenesis. Also provided are methods of treating tissue in disease or injury by local transplantation with an effective amount of the autologous bone marrow-mononuclear cells so as to induce vascularization in such diseased tissue.
REFERENCES:
patent: WO 0120999 (2001-03-01), None
Kobayashi et al (J. Surgical Res. Apr. 2000; 89(2):189-95).*
Prockop D (Science 1997; 276:71-74).*
Hamano, K. et al. “The Induction of angiogenesis by the implantation of autologus bone marrow cells: A novel and simple therapeutic method”, Surgery, Jul. 2001, vol. 130, No. 1, pp. 44-54.
Kalka, C. et al. “Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization”, PNAS, Mar. 28, 2000, vol. 97, No. 7, pp. 3422-3427.
Shintani S., et al., “Local transplantation of Autologus bone marrow-derived mononuclear cells augments collateral vessel formation in ischemic hindlimb in rabbits”, Circulation, Nov. 2, 1999, vol. 100, No. 18, p. I.406, Abstract.
Ueno, T. et al., “Therapeutic angiogenesis by bone marrow-derived cell transplantation in pigs with coronary constrictor-induced chronic myocardial ischemia”,J Am Col Cardiol, Feb., 2001, vol. 37, No. 2, Supplement A, p. 48A, Abstract.
Baldwin Sam
Chronos Nicolas A. F.
Murohara Toyoaki
Palasis Maria
Robinson Keith Allen
Boston Scientific Scimed Inc.
Kenyon & Kenyon
Nickel G.
Yaen C.
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