Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2009-04-03
2011-10-18
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C530S300000, C435S005000
Reexamination Certificate
active
08039001
ABSTRACT:
Embodiments of the present invention provide compositions including a complexes of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. Other embodiments also provide complexes comprising chimeras of papillomavirus L2 polypeptides non-covalently associated with papillomavirus L1 polypeptides, and GST fusions thereof. These compositions may be used to elicit immune responses in a patient to papillomavirus. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infection, especially papillomavirus infection and cervical cancers and warts associated therewith, made from compositions of this invention, are also disclosed. Nucleic acids and expression vectors coding for compositions are also disclosed.
REFERENCES:
patent: 6165471 (2000-12-01), Garcea et al.
patent: 7670607 (2010-03-01), Balloul et al.
patent: 7763259 (2010-07-01), Garcea et al.
Wakabayashi et al, Intervirology, 2002, vol. 45, pp. 300-307.
Chen, J. Mol. Biol., 2001, vol. 307, pp. 173-182.
Finnen Renee
Garcea Robert L.
Faegre & Benson LLP
Salimi Ali R.
The Regents of the University of Colorado, a body corporate
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