Therapeutic and prophylactic agent for gastrointestinal ulcers

Details Therapeutic and prophylactic agent for gastrointestinal ulcers Therapeutic and prophylactic agent for gastrointestinal ulcers

1988-03-03

1989-07-18

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530388, 514929, 514926, 514927, A61K 3718

Patent

active

048494046

ABSTRACT:
Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other groups. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.

REFERENCES:
patent: 4330620 (1982-05-01), Gruber et al.
Chem. Abst. 99:68657u, 1983.
Chemical Abstracts, vol. 99, No. 9, 29th Aug. 1983; M. Tsutomo, "Studies of Pharmalogical Activation . . . ".
Chem. Abstracts, citation of Green Cross Corp., vol. 96:205420r, 1982.

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