Therapeutic and diagnostic tools for impaired glucose...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C435S007100, C435S007400, C435S069100, C435S325000, C435S375000

Reexamination Certificate

active

07041437

ABSTRACT:
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.

REFERENCES:
patent: 5196333 (1993-03-01), Chalfie et al.
patent: WO 98/33907 (1998-08-01), None
patent: WO 98/51351 (1998-11-01), None
patent: WO 01/07457 (2001-02-01), None
Myers et al P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.PNAS 94:9052-9057, 1997.
Maehama et al The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.J Biol. Chem. 237(22):13375-13378, 1998.
Khan et al. Obesity and insulin resistance. J. Clin. Invest. 106(4):473-481, 2000.
Lonnqvist et al Overexpressin of the obese (ob) gene in adipose tisse of obese subjects. Nat. Med. 1(9):950-953, 1995.
Ogg et al, The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.Mol Cell 2:887 893, 1998.
Fontaine et al Years of life lost due to obesity. JAMA 289:187-193, 2003.
Shulman Cellular mechanisms of insulin resistance. J Clin. Invest. 106:171-176, 2000.
Hlrosumi et al. A central role for JNK in obesity and insulin resistance Nature.420(6913):333-6 2002.
GenBank 516083.
Fernandez-Almonacid et al., “Structure and Ligand Specificity of theDrosophila melanogasterInsulin Receptor,”Molecular and Cellular Biology7:2718-2727 (1987).
Garofalo et al., “Tissue Localization ofDrosophila melanogasterInsulin Receptor Transcripts During Development,”Molecular and Cellular Biology8:1638-1647 (1988).
Garcia-Jimenez et al., “Insulin Regulation of Malic Enzyme Gene Expression in Rat Liver: Evidence for Nuclear Proteins that Bind to Two Putative Insulin Response Elements,”Molecular Endocrinology8:1361-1369 (1994).
Graf et al., “Insulin-Mediated Secretion of Ecdysteroids From Mosquito Ovaries and Molecular Cloning of the Insulin Receptor Homologue from Ovaries of BloodfedAedes aegypti,” Insect Molecular Biology6:151-163 (1997).
Jonas et al., “Insulin Receptor inAplysiaNeurons: Characterization, Molecular, Cloning, and Modulation of Ion Currents,”The Journal of Neuroscience16:1645-1658 (1996).
Lee et al., “Structure and Localization of theIGFBP-1Gene and Its Expression During Liver Regeneration,”Hepatology19:656-665 (1994).
Petruzzelli et al., “Isolation of aDrosophilaGenomic Sequence Homologous to the Kinase Domain of the Human Insulin Receptor and Detection of the PhosphorylatedDrosophilaReceptor with an Anti-Peptide Antibody,”Biochemistry83:4710-4714 (1986).
Roovers et al., “Characterization of a Putative Molluscan Insulin-Related Peptide Receptor,”Gene162:181-1188 (1995).
Suwanickul et al., “Identification of an Insulin-Responsive Element in the Promoter of the Human Gene for Insulin-Like Growth Factor Binding Protein-1,”The Journal of Biological Chemistry288:17063-17068 (1993).
Allander, et al., Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter.Endocrinology, 138:4291-300 (1997).
Ahren et al., Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion.Diabetologia, 29:827-836 (1986).
Austad,Neurobiology of Ageing, 16(5):851-852 (1995).
Arpagaus, Vertebrate insulin induces diapause termination inPieris brassicaepupae.Roux's Arch. Dev. Biol., 196:527-530 (1987).
Baker et al., A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.Genes and Development, 10:1880-1889 (1996).
Bargmann et al., Control of larval development by chemosensory neurons inCaenorhabditis elegans. Science, 251;1243-1246 (1991).
Borkhardt et al., Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11) (q13; q23).Oncogene, 14:195-202 (1997).
Boschero, et al., Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3muscarinic receptors.Am. J. Physiol.,268:E336-E342, (1995).
Brown-Borg et al., Dwarf mice and the ageing process.Nature, 384:33 (1996).
Brüning eta l., Development of a novel polygenic model of NIDDM in mice heterozygous forIRandIRS-1 null alleles.Cell, 88:561-572 (1997).
Coleman, Obesity genes: beneficial effects in heterozygous mice.Science, 203:663-665 (1979).
Dorman et al., Theage-1 anddaf-2 genes function in a common pathway to control the lifespan ofcaenorhabditis elegans. Genetics, 141:1399-1406 (1995).
Ebina et al., the human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling.Cell, 40:747-758 (1985).
Estevez et al., Thedaf-4 gene encodes a bone morphogenetic protein receptor controllingC. elegansdauer larva development.Nature, 365:644-649 (1993).
Ewbank et al., Structural and functional conservation of theCaenorhabditis eleganstiming geneclk-1. Science, 275:980-983 (1997).
Fernandez et al., TheDrosophiainsulin receptor homolog: A gene essential for embryonic development encodes two receptor isoforms with different signaling potential.EMBO J.,14:3373-3384 (1995).
Galili et al., Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.Nat. Genet.,5:230-235 (1993).
Georgi et al.,daf-1, aC. elegansgene controlling dauer larva development, encodes a novel receptor protein kinase.Cell, 61:635-645 (1990).
Gil et al., Regulation of the insulin-like development pathway ofCaenorhabditis elegansby a homolog of the PTEN tumor suppressor gene.Proc. Natl. Acad. Sci. USA, 96:2925-2930 (1999).
Golden et al., TheCaenorhabditis elegansdauer larva: development effects of pheromone, food, and temperature.Development Biology, 102:368-378 (1984).
Golden et al., A pheromone-induced development switch inCaenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process.Proc. Natl. Proc. Acad. Sci. U.S.A.,81:819-823 (1984).
Gottlieb et al.,daf-2, daf-16anddaf-23:Genetically interacting genes controlling dauer formation inCaenorhabditis elegans. Genetics, 137:107-120 (1994).
Graff et al., Xenopus MAD proteins transduce distinct subsets of signals for the TGFB superfamily.Cell, 85:479-487 (1996).
Green et al., Responses of embryonic Xenopus cells to activin and FGF are separated by mulitple dose thresholds and correspond to distinct axes of the mesoderm.Cell, 71:731-739 (1992).
Hahn et al.,DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.Science, 271:350-353 (1996).
Hemmings, Akt signaling: linking membrane events to life and death decisions.Science, 275:628-630 (1997).
Hetru et al., Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide fromLocusta migratoria. Eur. J. Biochem.,201:495-499 (1991).
Hillion, et al., AF6q21 a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily,Blood, 90:3714-9 (1997).
Hobert, et al., Regulation of interneuron function in theC. elegansthermoregulatory pathway by thettx'LIM homeobox gene.Neuron, 19:345-357 (1997).
Hoodless et al., MADR1, a MAD-related protein that functions in BMP2 signaling pathways,Cell, 85:489-500 (1996).
Hotamisligil et al., Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance.Science, 259:87-91 (1993).
Hubbard et al., Crystal structure of the tyrosine kinase domain of the human insulin receptor.Nature, 372:746-754 (1994).
Jonas et al., Regulatory by insulin of a unique neuronal Ca2+pool and of neuropeptide secretion.Nature, 385:343-346 (1997).
Kahn et al., Genetics of non-insulin-dependent (Type-II) diabetes mellitus.Annu. Rev. Med.,47:509-531 (1996).
Kawakami et al., Molecular cloning of theBombyx Moriprothoracicotropic hormone.Science, 247:1333-1335 (1990).
Kenyon et al., AC. elegansmutant that lives twice as long as wild type.Nature, 366:461-464 (1993).
Kim et al., Detection of mutations in the insulin recepto

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic and diagnostic tools for impaired glucose... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic and diagnostic tools for impaired glucose..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic and diagnostic tools for impaired glucose... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3582286

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.