Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2005-03-01
2005-03-01
Fredman, Jeffrey (Department: 1636)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S069100, C435S320100, C435S325000, C435S455000, C800S003000, C800S008000, C800S009000, C536S023100, C536S023500, C424S009200
Reexamination Certificate
active
06861256
ABSTRACT:
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions.
REFERENCES:
patent: 5196333 (1993-03-01), Chalfie et al.
patent: WO 9833907 (1998-08-01), None
patent: WO 9851351 (1998-11-01), None
patent: WO 0107457 (2001-02-01), None
Curt D. Sigmund, Viewpoint: Are Studies in Genetically Altered Mice Out Of Conttrol?, Jun. 20, 2000 (6): 1425-9.*
Philip A. Wood, Phenotype Assessment: Are You Missing Something?, Comp Med Feb 2000; 50 (1): 12-5.*
Catherine A. Kappel et al, regulating gene expression in transgenic animals, 1992, 3:548-553.*
V.G.Pursel et al, Expression and performance in transgenic pigs, J Reprod. Fert. Suppl, 40 (1990), 235-245.*
Scott Ogg et al, TheC. elegansPTEN Homolog, DAF-18, Acts in the insulin Receptor-like Metabolic Signaling Pathway, Molecular Cell, vol. 2, 887-893, Dec., 1998.*
Well RJ, Theriongenology 45:57-68, 1996.*
Larsan et al, Genetics 139:1567-1583, 1995.*
Lonngvist et al Nat. Med. 1(9):950-953, 1995.*
Zeman et al, Atherosclerosis, 134(1-2):318, 1997.*
Kimura et al, Science 277: 942-946, 1997.*
Austad, Neurobiology of Ageing 16(5):851-852, 1995.*
Maehama et al., “The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-triphosphate,”J. Biol. Chem.273:13375-13378 (1998).
Mihaylova et al., “The PTEN tumor suppressor homolog inCaenorhabditis elegansregulates longevity and dauer formation in an insulin receptor-like signaling pathway,”Proc. Natl. Acad. Sci. USA96:7427-32 (1999).
Rouault et al., “Regulation of dauer larva development inCaenorhabditis elegansby daf-18, a homologue of the tumour suppressor PTEN,”Current Biol.9:329-332 (1999).
Scheet et al., “Direct Submission: T07A9.6 protein (DAF-18 protein),” (Accession No. 044405) European Bioinformatics Institute, European Molecular Biology Laboratory (1998).
Stephens et al., “Protein kinase B kinases that mediated phosphatidylinositol 3, 4, 5—trisphosphate-dependent activation of protein kinase B,”Science279:710-714 (1998).
TheC. elegansSequencing Consortium, “Genome sequence of the nematodeC. elegans:A platform for investigating biology,” Science, 282:2012-2018 (1998).
Waterston, “Direct Submission:Caenorhabditis eleganscosmid TO7A9,” (Accession No. AF036706) European Bioinformatics Institute, European Molecular Biology Laboratory (1997).
Parrizas et al., “Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins,”Endocrinology138:1427-1433 (1997).
Gil et al., “Regulation of the Insulin-Like Developmental Pathway ofCaenorhabditis elegansby a Homolog of the PTEN Tumor Suppressor Gene,” Proc. Natl. Acad. Sci. USA 96:2925-2930 (1999).
Arpagaus, Vertebrate insulin induces diapause termination inPieris brassicaepupae,Roux's Arch. Dev. Biol.,196:527-530 (1987).
Baker et al., A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway,Genes and Development,10:1880-1889 (1996).
Bargmann et al., Control of Larval Development by Chemosensory Neurons inCaenorhabditis elegans, Science,251:1243-1246 (1991).
Brown-Borg et al., Dwarf mice and the ageing process,Nature,384:33 (1996).
Brüning et al., Development of a Novel Polygenic Model of NIDDm in Mice Heterozygous for IR and IRS-1 Null Alleles,Cell,88:561-572 (1997).
Coleman, Obesity Genes: Beneficial Effects in Heterozygous Mice,Science,203:663-665 (1979).
Dorman et al., The age-1 and daf-2 Genes Function in a Common Pathway to Control the Lifespan ofCaenorhabditis elegans, Genetics,141:1399-1406 (1995).
Ebina et al., The Human Insulin Receptor cDNA: The Structural Basis for Hormone-Activated Transmembrane Signalling,Cell,40:747-758 (1985).
Estevez et al., The daf-4 gene encodes a bone morphogenetic protein receptor controllingC. elegansdauer larva development,Nature,365:644-649 (1993).
Ewbank et al., Structural and Functional Conservation of theCaenorhabditis elegansTiming Gene clk-1,Science,275:980-983 (1997).
Fernandez et al. The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes tow receptor isoforms with different signaling potential,EMBO J.,14:3373-3384 (1995).
Galili et al., “Fusion of a fork head domain gene to PAX3 in the Solid Tumour Alveolar Rhabdomyosarcoma,” Nat. Genet. 5:230-235 (1993).
Georgi et al., daf-1, aC. elegansGene Controlling Dauer Larva Development, Encodes a Novel Receptor Protein Kinase,Cell,61:635-645 (1990).
Golden et al., TheCaenorhabditis elegansDauer Larva: Developmental Effects of Pheromone, Food, and Temperature,Developmental Biology,102:368-378 (1984).
Golden et al., A pheromone-induced developmental switch inCaenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process,Proc. Natl. Proc. Acad. Sci. U.S.A.,81:819-823 (1984).
Gottlieb et al., daf-2, daf-16 and daf-23: Genetically Interacting Genes Controlling Dauer Formation inCaenorhabditis elegans, Genetics,137:107-120 (1994).
Graff et al., Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily,Cell,85:479-487 (1996).
Green et al., Responses of Embryonic Xenopus Cells to Activin and FGF Are Separated by Multiple Dose Thresholds and Correspond to Distinct Axes of the Mesoderm,Cell,71:731-739 (1992).
Hahn et al.,DPC4,A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1,Science,271:350-353 (1996).
Hemmings, Akt Signaling: Linking Membrane Events to Life and Death Decisions,Science,275:628-630 (1997).
Hetru et al., Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide fromlocusta migratoria Eur. J. Biochem.,201:495-499 (1991).
Hoodless et al., MADR1 a MAD-Related Protein That Functions in BMP2 Signaling Pathways,Cell,85:489-500 (1996).
Hotamisligil et al., Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance,Science,259:87-91 (1993).
Hubbard et al., Crystal structure of the tyrosine kinase domain of the human insulin receptor,Nature,372:746-754 (1994).
Jonas et al., Regulation by insulin of a unique neuronal Ca2+pool and of neuropeptide secretion,Nature,385:343-346 (1997).
Kahn et al., Genetics of Non-Insulin-Dependent (Type-II) Diabetes Mellitus,Annu. Rev. Med.,47:509-531 (1996).
Kawakami et al., Molecular Cloning of theBombyx moriProthoracicotropic Hormone,Science,247:1333-1335 (1990).
Kenyon et al., AC. elegansmutant that lives twice as long as wild type ,Nature,366:461-464 (1993).
Kim et al., Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms,Diabetologia,35:261-266 (1992).
Kimble, Alterations in Cell Lineage following Laser Ablation of Cells in the Somatic Gonad ofCaenorhabditis elegans, Developmental Biology,87:286-300 (1981).
Kimura et al., “daf-2, an Insulin Receptor-Like Gene That Regulates Longevity and Diapause inCaenorhabditis elegans,” Science277:942-946 (1997).
Klass, A Method for the Isolation of Longevity Mutants in the NematodeCaenorhabditis elegansand Initial Results,Mechanisms of Ageing and Dev.,22:279-286 (1983).
Krause, Transcription and Translation, Chapter 20,Methods Cell Biol.,Academic Press, San Diego, CA, 48:483-512 (1995).
Krawczak et al., The human gene mutation database,Trends Genet13:121-2 (1997).
Lagna et al., Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways,Nature,383:832-836 (1996).
Larsen et al., Genes that Regulate Both Development and Longevity inCaenorhabditis elegans, Genetics,139:1567-1583 (1995).
Lin et al., “daf-16: An HNF-3/Forkhead Family Member That Can Function to Double the Life-Span ofCaenorhabditis elegans,” Science278:1319-1322 (1997).
Liu et al., A human Mad protein acting as a BMP-regulated t
Ogg Scott
Ruvkun Gary
Clark & Elbing LLP
Fredman Jeffrey
Kaushal Sumesh
The General Hospital Corporation
LandOfFree
Therapeutic and diagnostic tools for impaired glucose... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutic and diagnostic tools for impaired glucose..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic and diagnostic tools for impaired glucose... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3398178