Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1989-11-09
1994-03-08
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 723, 435 724, 435 79, 435 794, 435 34, 435974, 435975, 436506, 436518, 436536, 436548, 436811, 436813, G01N 33543, G01N 33564, G01N 33574, G01N 33577
Patent
active
052926362
ABSTRACT:
The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis, staging, and therapy of diseases and disorders. Specific embodiments involve the diagnosis and monitoring of therapy using absolute values of such soluble molecules. Further embodiments involve detecting a change in the levels of such soluble molecules, in the diagnosis and therapy of diseases and disorders. In specific embodiments, measurements of interleukin-2 receptor levels can be made to detect lung cancer, or to stage squamous cell lung carcinoma. In other embodiments, detection of increases in both soluble IL2R and creatinine in the body fluid of a transplant patient can be used to differentially diagnose renal allograft rejection from infection. The invention is also directed to methods for measurement of soluble CD4 antigens, which measurements can be used, in a specific embodiment, to diagnose a state of immune activation, to diagnose rheumatoid arthritis, to monitor therapeutic efficacy (e.g. of AIDS treatments), or to stage adult T cell leukemia in a patient. In another aspect, the invention relates to the detection, staging, and monitoring of therapy of diseases and disorders by measuring a plurality of soluble T cell markers.
REFERENCES:
patent: 4299916 (1981-11-01), Litman et al.
patent: 4350683 (1982-09-01), Galfre et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4472500 (1984-09-01), Milstein et al.
patent: 4645738 (1987-02-01), Knowles et al.
patent: 4707443 (1987-11-01), Nelson et al.
patent: 4845026 (1989-07-01), Kung et al.
Berger et al Proc. Natl. Acad. Sci. USA, 85, 2357-2361, 1988.
Sattentau et al, Jour. Exp. Med., 170, 1319.sub.]1334, 1989.
Gay et al., Nature 328:626-629, (1987).
Dagleish et al., Immunol. Today 7:142-143, (1986).
Sattentau et al., Cell 52:631-633, (1988). 1319-
Fisher et al., Nature 331:76-78, (1988).
Germain et al., Cell 54:4411-444, (1988).
Weiss et al., Nature 331:15, (1988).
Siliciano et al., Cell 54:561-575, (1988).
Hussey et al., Nature 331:78-81, (1988).
Madden et al., Cell 42:93-104, (1985).
Littman et al., Nature 325:453-455, (1987).
Traunecker et al., Nature 331:84-86, (1987).
Smith et al., Science 328:1704-1707, (1987).
Deen et al., Nature 331:82-84, (1988).
Doyle et al., Nature 330: 256-259, (1987).
Booth et al., News & Comment, Science 239:341-343, (1988).
Meuer et al., Proc. Natl. Acad. Sci USA 79:4395-4399, (1982).
Kung et al., Monoclonal Antibodies in Clinical Investigations, Clinical Biochemistry-Contemporary Theories and Techniques, vol. 3, Academic Press pp. 89-115, (1984).
Biddison et al., J. Exp. Med. 159:783, (1984).
Hoxie et al., J. Immunol, 137:1194-1201, (1986).
Snow et al., J. Biol. Chem. 258:14675-14681, (1983).
Doumerc et al., 1986 6th Intl. Congress of Immunology, Toronto, Ontario, Canada, Jul. 1986, Abstr. 5.54.6., p. 768.
Kung et al., Clin. Chem. 34:1340 (1988).
Swain et al., Proc. Natl. Acad. Sci. U.S.A. 78:7101-7105 (1981).
Francus et al., J. Immunol. 140:1823-1829 (1988).
Greene et al., Ann. Intern. Med. 105:560-572 (1986).
Rubin et al., in Leukocytes and Host Defense, Oppenheim, J. J., and D. M. Jacobs, eds., Alan R. Liss, Inc., New York, pp. 95-102, (1986).
Yasuda et al., Blood 71:1021-1026 (1988).
Steis et al., Blood 71:1304-1309 (1988).
Pui et al., Blood 71:1135-1137 (1988).
Wolf et al., Arth. Rheum. 31:729-735 (1988).
Stolc et al., Diag. Clin. Immunol. 5:171-174 (1987).
Sethi et al., Immunol. Lett. 13:179-184 (1986).
Tomkinson et al., J. Immunol. 139:3802-3807 (1987).
Tomkinson et al., 1987, Released CD8 levels in immune activation, 2nd Annual Conference on Clinical Immunology, Washington, D.C.
Carpenter et al., Assessment of soluble CD8 and IL-2 receptor in the serum and synovial fluid from rheumatoid arthritis, 52nd Ann. Mtg., Am. Rheum. Assoc., Abstr., (1988).
Rubin et al., Chem. Abstr. vol. 104 No. 21, p. 489 abstract No. 184611, (May 26, 1986).
Rubin et al., (1985), Federation Proceedings, 69th Annual Mtg., Anaheim, California, vol. 44, No. 4, Apr. 21-26, 1985, Abstract 3131, pp. 946, Mar. 5, 1985.
Fujimoto et al., J. Exp. Med. 160:116-124, Jul. 1984.
Snow et al., The Journal of Biological Chemistry 260:2700-2708 (1985).
Snow et al., The Journal of Immunology 135:3172-3177, (1984).
Rubin et al., The Journal of Immunology 135:3172-3177, Nov. 1985.
Rubin et al., Clin Research, vol. 33, No. 2, p. 388A, (Apr. 1986).
Osawa et al., Eur. J. Immunol., 467-469, (1986).
Nelson et al., Journal of Clinical Immunology 6:114.sub.]120, (1986).
Mackeen et al., Fed. Proc., 45:457, Ab. No. 1746, (1986).
Nelson et al., Fed. Proc., vol. 45, No. 3, Abs. 1294, (Mar. 1, 1986).
Rubin et al., Clin. Res., 33, 457A, Apr. 1986.
Saadeh et al., Fed. Proc., vol. 45, No. 3, Abs. 1298 (1986).
De Moyos et al., FASEB Abstract Form Received at Society Office by Tuesday, Dec. 8, 1987.
Greaves et al., Int J. Immunopharmac. 3(3):283-300, (1981).
Rao et al., Cell Immunol. 80:310, (1983).
Baldwin et al., Monoclonal Antibodies for Cancer Detection and Therapy, p. 20, Karl Erik Hellstrom and Hellstron, (1985).
Kung et al., Science 206:347-349 (1979).
Reinherz et al, Proc. Natl. Acad. Sci. U.S.A. 76:4061-4065 (1979).
Reinherz et al., Proc. Natl. Acad. Sci. U.S.A. 77:1588-1592 (1980).
Verbi et al., Eur. J. Immunol. 12:81-86 (1982).
Kanellopoulos et al., The EMBO J. 2:1807-1814 (1983).
Kung et al., Int. J. of Dermatol. 22:67-74 (1983).
Krensky and Clayberger, Transplantation 39:339-348 (1985).
McDougal et al., Science 231:382-385 (1986).
Miller et al., Blood 58(1):78-86 (1981).
Falcao et al., J. Clin. Lab. Immunol. 13:141-143 (1984).
Oh et al., Scan. J. Immunol. 22:51-60 (1985).
Acuto et al., Cell 34:717-726 (1983).
Brenner et al., J. Exp. Med. 160:541-551 (1984).
Meuer et al., Proc. Natl. Acad. Sci. U.S.A. 81:1509-1513. (1984a).
Meuer et al., Ann. Rev. Immunol. 2:23-50 (1984b).
McKenzie and Parrish, J. Exp. Med. 144:847-851 (1976).
Parish et al., Immunogenetics 3:129-137 (1976).
Parish and McKenzie, Cellular Immunol. 33:134-144 (1977).
Parish et al, Infection and Immunity 26:422-426 (1979).
Wilson et al., J. Immunol. 122:1967-1971 (1979).
Sandrin et al., J.N.C.I. 66:279-283 (1981).
Mier and Gallo, Proc. Natl. Acad. Sci. U.S.A. 77:6134-6138 (1980).
Smith, Immunol. Rev. 51:337-357 (1980).
Arya et al., Science 223:1086-1087 (1984).
Lotze et al., J. Immunol. 135:2865-2875 (1985).
Touw et al., Blood 66:556-561 (1985).
Robb et al., J. Exp. Med. 154:1455-1474 (1981).
Uchiyama et al., J. Immunol. 126:1393-1397 (1981).
Leonard et al., Nature 300:267-269 (1982).
Korsmeyer et al., Proc. Natl. Acad. Sci. U.S.A. 80:4522-4526 (1983).
Depper et al., J. Immunol. 133:1691-1695 (1984).
Sugamura et al., Proc. Natl. Acad. Sci. U.S.A. 81:7441-7445 (1984).
Tsudo et al., J. Exp. Med. 160:612-617 (1984).
Waldmann et al., J. Exp. Med. 160:1450-1466 (1984).
Dower et al., J. Exp. Med. 162:501-515 (1985).
Ebert et al., Clin Immunol. and Immunopathol. 37:283-297 (1985).
Rubin et al., Hybridoma 4:91-102 (1985).
Uchiyama et al., J. Clin. Invest. 76:446-453 (1985).
Greene and Leonard, Ann. Rev. Immunol. 4:69-95 (1986).
Gupta, Clin. Immunol. and Immunopathol. 38:93-100 (1986).
Mutsuoka et al., Leukemia Res. 10:597-603 (1986).
Tsudo et al., Blood 67:316-321 (1986).
Tuow et al., Blood 68:1088-1094 (1986).
Chilosi, et al., Int. J. Biological Markers 2:101-104 (1986).
Durno et al., Blood 68 Suppl. #1,124a (1986).
John et al., Sixth Int. Cong. Immunol. Toronto, Canada (1986).
Keller et al., Am. Diabetes Assoc. (1986).
Nelson et al., Pediatric Res. 20:136-139 (1986).
Pizzolo et al., Blood 68 Suppl. #1, 228a (1986).
Reuben et al., Blood 68 Suppl. #1, 213a (1986).
Rubin et al., J. Immunol. 137:3841-3844 (1986).
Treiger et al., J. Immunol. 136:4099-4105 (1986).
van Es et al., Transplantation 37:65-69 (1984).
Austen and Cosimi, N. Engl. J. Med. 311:1436-1438 (1984).
Hancock et al., Transplantation 39:430-438 (1985).
Magrath et al., Blood 63:1102-1111 (1984).
Pui et al., Blood 66:778-782 (198
Brown Michael C.
Ip Stephen H.
Kung Patrick C.
MacKeen Linda A.
Saunders David
T Cell Diagnostics, Inc.
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