Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-06-25
1998-07-28
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 792, 436 63, 436 64, 436813, 436815, 436811, G01N 33574, G01N 3353
Patent
active
057861587
ABSTRACT:
The present invention relates to diagnostic methods and compositions for detection of malignancy or nervous system disorders based on the level of Notch proteins or nucleic acids. Therapeutic methods and methods of inhibiting Notch expression are also provided.
REFERENCES:
patent: 5115096 (1992-05-01), Shoyab et al.
patent: 5132212 (1992-07-01), Kirsch et al.
patent: 5264557 (1993-11-01), Salomon et al.
Welshons, 1965, Analysis of a gene is Drosophila with variations, the genes of microorganisms and those of Drosophila are much the same, Science 150:1122-1129.
Portin, 1975, Allelic negative complementation at the abruptex locus of Drosophila melanogaster, Genetics 81:121-133.
Morita et al., 1984, Derivates of blood coagulation factor IX contain a high affinity Ca.sup.2+ -binding site that lacks .gamma.-carboxyglutamic acid, J. Biol. Chem. 259:5698-5704.
Sugo et al., 1984, Calcium-binding properties of bovine factor X lacking the .gamma.-carboxyglutamic acid-containing region, J. Biol. Chem. 259:5705-5710.
Lindsley and Zinn, 1985, Drosophila Information Service 62:86.
Sudhof et al. 1985, The LDL receptor gene: a mosaic of exons shared with different proteins, Science 228:815-822.
Doe and Goodman, 1985, Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells, Dev. Biol. 111:206-219.
Vassin et al., 1985, Genetic interactions in early neurogenesis if Drosophila melanogaster , J. Neurogenet. 2:291-308.
Wharton et al., 1985, Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats, Cell 43:567-581.
Kidd et al., 1965 Sequence of the Notch Iocus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors, Mol. Cell. Biol. 6:3094-3108.
Breeden and Nasmyth, 1987, Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila Nature 329:651-654.
Appella et al., 1987, The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases, J. Biol. Chem. 262:4437-4440.
Knust et al., 1987, EGF homologous sequences encoded in the genome of Drosophila melanogaster , and their relation to neurogenic genes, EMBO J. 6(3):761-766.
Suzuki et al., 1987, Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation, EMBO J. 6(7):1891-1897.
Hartley et al., 1987, The embryonic expression of the Notch locus of Drosophila melanogaster and the implcations of point mutations in the extracellular EGF-like domain of the predicted protein, EMBO J. 6(11):3407-3417.
Reynolds et al., 1987, Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the .beta.T cell receptor gene in human lymphoblastic neoplasms, Cell 50:107-117.
Vassin et al., 1987, The neurogenic gene Delta of Drosophila melanogasteris expressed in neurogenic territories and endcodes a putative transmembrane protein with EGF-like repeats, EMBO J. 6:3431-3440.
Kelley et al., 1987, Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus, Cell 51:539-548.
Kopczynski et al., 1988, Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates, Genes & Dev. 2:1723-1735.
Kopczynski and Muskavitch, 1989, Complex spatio-temporal accumulation of alternative transcripts from the neurogenic gene Delta during Drosophila embryogensis , Development 107:623-636.
Rees et al., 1988, The role of .beta.-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX, EMBO J. 7(7):2053-2061.
Furie and Furie, 1988, The molecular basis of blood coagulation, Cell 53:505-518.
Artavanis-Tsakonas, 1988, DNA, differentiation & development, Trends in Genetics 4:95-100.
Kurosawa et al., 1988, A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site, J. Biol. Chem. 263(13):5993-5996.
Yochem et al., 1988, The Caenorhabditis elegans lin -12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch, Nature 335:547-550.
Rothberg et al., 1988, slit : An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system, Cell 55:1047-1059.
Kidd et al., 1989, Structure and distribution of the Notch protein in developing Drosophila, Genes & Dev. 3:1113-1129.
Johansen et al., 1989, The Notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development, J. Cell Biol. 109:2427-2440.
Shepard et al., 1989, A tripartite interaction among alleles of Notch, Delta,and Enhancer of split during imaginal development of Drosophila melanogaste , Genetics 122:429-438.
Alton et al., 1989, Molecular genetics of Delta , a locus required for ectodermal differentiation in Drosophila , Dev. Genet. 10:261-272.
Handford et al., 1990, The first EGF-like domain from human factor IX contains a high-affinity calcium binding site, EMBO J. 9:475-480.
Fehon et al., 1990, Molecular interactions between the protein products of the neurogenic loci Notch and Delta , two EGF-homologous genes in Drosophila, Cell 61:523-534.
Coffman et al., 1990, Xotch, the Xenopus homolog of Drosophila Notch , Science 249:1438-1441.
Palka et al., 1990, Neurogenic and antineurogenic effects from modifications at the Notch locus, Develop. 109:167-175.
Xu et al., 1990, The Notch Locus and the egenetic circuitry involved in early Drosophila neurogenesis, Genes & Dev. 4:464-475.
Weinmaster et al., 1991, A homolog of Drosophila Notch expressed during mammalian development, Develop. 113:199-205.
Fehon et al., 1991, Complex spatial and temporal regulation of Notch expression during embryonic and imaginal development of Drosophila , implications for Notch function, J. Cell Biol. 113:657-669.
Coffman et al., 1993, "Expression of an extracellular deletion of xotch diverts cell fate in xenopus embryos", Cell 73:659-671.
Adams et al., 1991, Science 252:1651-1656.
Stifani et al., 1992, Nature Genetics 2(2):119-127.
Weinmaster et al., 1992, Development 116(4):931-941.
Croce, 1987, "Role of Chromosome Translocations in Human Neoplasia", Cell 49:155-156.
Borrow and Solomon, 1992, "Molecular Analysis of the t(15;17) translocation in acute promyelocytic leukaemia", Bailliere 's Clinical Hematology 5(4):833-856.
Jhappan et al., 1992, "Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands", Genes & Dev. 6:345-355.
Robbins et al., 1992, "Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells", J. Viol. 66:2594-2599.
Campos-Ortega and Knust, 1990, "Molecular analysis of a cellular decision during embryonic development of Drocophila melasnogaster : epidermogenesis or neurogensis", Eur. J. Biochem. 190:1-10.
De Celis et al., 1993, "Genetic and molecular characterization of a Notch mutation in its Deta- and Serrate-binding domain in Drosophila ", Proc. Natl. Acad. Sci. USA 90:4037-4041.
Greenspan, 1990, "The Notch gene, adhesion, and developmental fate in the Drosophila embryo, "New Biologist 2(7):595-600.
Rebay et al., 1991, "Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor, "Cell 67:687-699.
Robbins et al., 1992, "Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells, " Biol. Abstr. 93(11):AB-465 (Abstr. 122736).
Ellisen, L.W., et al., Cell , vol.66, pp. 649-661, Aug. 23, 1991.
Artavanis-Tsakonas Spyridon
Blaumueller Christine Marie
Fehon Richard Grant
Zagouras Panayiotis
Scheiner Toni R.
Yale University
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