Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1995-06-07
1998-11-24
Coggins, Wynn Wood
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 93, 606 45, 607120, 607122, A61M 3100
Patent
active
058400591
ABSTRACT:
A system for treating a patient's heart which comprises a means to form channels in the heart wall and a means to deliver a therapeutic or diagnostic agent into the channels. Additionally, the system may comprise a way to retain the agent within the channels for a useful period of time. The system may be configured to be introduced percutaneously or intraoperatively. The system generally comprises an elongated, flexible lasing transmission catheter that emits laser radiation and has delivery lumen opening at the distal end. Practice of the invention comprises forming channels in the heart wall and delivering a therapeutic or diagnostic agent into the channel. Gene therapy agents of this invention comprise vectors for transferring genetic information to the heart tissue in vivo or harvested cells which have been genetically engineered in vitro. Additionally, the invention may comprise retaining the agent within the channels, for example, by incorporating the agent in a viscous carrier.
REFERENCES:
patent: 5213570 (1993-05-01), VanDeripe
patent: 5269326 (1993-12-01), Verrier
patent: 5302706 (1994-04-01), Smith
patent: 5431649 (1995-07-01), Mulier et al.
patent: 5433700 (1995-07-01), Peters
patent: 5484384 (1996-01-01), Fearnot
patent: 5500012 (1996-03-01), Brucker et al.
patent: 5545193 (1996-08-01), Fleischman et al.
patent: 5571151 (1996-11-01), Gregory
patent: 5578007 (1996-11-01), Imran
Elizabeth G. Nagel et al., Site Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall, Science,vol. 249, 14 Sep. 1990, 1285-1288.
Elizabeth G. Nabel et al., "Recombinant Platelet-derived Growth Factor B Gene Expression in Porcine Arteries Induces Intimal Hyperplasia In Vivo," J. Clin. Invest., vol. 91, Apr. 1993, 1822-1829.
Marsha F. Goldsmith, "Tomorrow's Gene Therapy Suggests Plenteous, Patent Cardiac Vessels," JAMA, Dec. 16, 1992, vol. 268, No. 23, 3285-3286.
W. Siegfried, "Perspectives in Gene Therapy with Recombinant Adenoviruses," Exp. Clin. Endocrinol., 101 (1993) 7-11.
Raul J. Guzman et al., "Efficient Gene Transfer Into Myocardium by Direct Injection of Adenovirus Vectors," Circulation Research, vol. 73, No. 6, Dec. 1993, 1202-1207.
Brent A. French, Ph.D. et al., "Direct In Vivo Gene Transfer Into Porcine Myocardium Using Replication-Deficient Adenoviral Vectors," Circulation, vol. 90, No. 5, Nov. 1994, 2414-2424.
Lorrie A. Kirshenbaum et al., "Highly Efficient Gene Transfer into Adult Ventricular Myocytes by Recombinant Adenovirus," J. Clin. Invest., vol. 92, Jul. 1993, 381-387.
Hua Lin, M.D. et al., "Expression of Recombinant Genes in Myocardium In Vivo After Direct Injection of DNA," Circulation, vol. 82, No. 6, Dec. 1990, 2217-2221.
James M. Wilson, M.D., Ph.D. et al., "Clinical Protocol, Ex Vivo Gene Therapy of Familial Hypercholesterolemia," Hum. Gene Ther., 3:179:222 (1992).
Moshe Y. Flugelman, M.D. et al., "Low Level In Vivo Gene Transfer Into the Arterial Wall Through a Perforated Balloon Catheter," Circulation, vol. 85, No. 3, Mar. 1992, 1110-1117.
Carmel M. Lynch et al., "Long-term expression of human adenosine adeaminase in vascular smooth muscle cells of rats: A model for gene therapy," Proc. Natl. Acad. Sci. USA, vol. 89, Feb. 1992, 1138-1142.
David A. Dicheck, M.D. et al., "Seeding of Intravascular Stents With Genetically Engineered Endothelial Cells," Circulation, vol. 80, No. 5, Nov. 1989, 1347-1353.
Guy Leclerc et al., "Percutaneous Arterial Gene Transfer in a Rabbit Model," J. Clin. Invest., vol. 90, Sep. 1992, 936-944.
Elizabeth G. Nabel et al., "Site-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall," Science, vol. 249, 14 Sep. 1990, 1285-1288.
Terrence X. O'Brien, M.D. et al., "Heart-to-Heart, New Approaches For Gene Transfer in the Myocardium," Circulation, vol. 83, No. 6, Jun. 1991, 2133-2136.
James M. Wilson et al., "Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells," Science, vol. 244, 16 Jun. 1989, 1344-1346.
Aita Michael
Kesten Randy
March Keith L.
Smith Craig
Byveis Deborah
CardioGenesis Corporation
Coggins Wynn Wood
Columbia University
Indiana University Foundation
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