Therapeutic amides

Details Therapeutic amides Therapeutic amides

2006-09-19

2006-09-19

Qazi, Sabiha N. (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C504S235000, C504S247000

Reexamination Certificate

active

07109341

ABSTRACT:
The invention provides compounds of the formula:wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.

REFERENCES:
patent: 4559157 (1985-12-01), Smith et al.
patent: 4608392 (1986-08-01), Jacquet et al.
patent: 4629493 (1986-12-01), Ura et al.
patent: 4710507 (1987-12-01), Campbell et al.
patent: 4760066 (1988-07-01), Busse et al.
patent: 4820508 (1989-04-01), Wortzman
patent: 4938949 (1990-07-01), Borch et al.
patent: 4992478 (1991-02-01), Geria
patent: 5250690 (1993-10-01), Turner et al.
patent: 5364831 (1994-11-01), Ura et al.
patent: 6103913 (2000-08-01), Hay et al.
patent: 6133457 (2000-10-01), Patel
patent: 6160006 (2000-12-01), Edwards et al.
patent: 6197728 (2001-03-01), Ura et al.
patent: 6238644 (2001-05-01), Rillema
patent: 6252064 (2001-06-01), Martinelli et al.
patent: 6352991 (2002-03-01), Zemlicka et al.
patent: 6586461 (2003-07-01), Gibbs
patent: 6680311 (2004-01-01), Al-Awar et al.
patent: 6703415 (2004-03-01), Mobashery et al.
patent: 6747021 (2004-06-01), Corbett et al.
patent: 6790841 (2004-09-01), Zemlicka et al.
patent: 6867219 (2005-03-01), Horwitz et al.
Draetta et al “Section V. Topics in Biology”, Annual Reports in Medicinal Chemistry, 31, 1996, Academic Press, San Diego, pp. 241-246.
Joseph R. Bertino and Sydney E. Salmon “Principles of Cancer Therapy”, Oncology XIV, pp. 1060-1074, 21stEdition, vol. 1 (2000), Edited by Lee Goldman, M.D. and J. Claude Bennett, M.D..
Balasubramanian et al “Recent Developments in Cancer, Etc.” Annual Reports in Medicinal Chemistry, 33, 1998, Academ Press, San Diego, pp. 151-159.
Hazeldine et al “Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent,” AN 2001:301100 Hcaplus, DN 135:76849, Journal of Medicinal Chemistry, (2001), 44(11), 1758-1776.
Corbett, T. H., “Preclinical Antitumor Efficacy of Analogs of XK469: Sodium-(2-[4-(7-Chloro-2-Quinoxalinyloxy)Phenoxy]Propionate”,Investigational New Drugs, 16. (1998),129-139.
Hazeldine, Stuart T., “J. Med. Chem., 2002, 45”,ll. Synthesis and Biological Evaluation of Some Bioisosteres and Congeners of the Antitumor Agent, 2-{4-(7-Chloro-2-quinoxalinyl)oxylphenoxy}propionic Acid(XK469), (2002),3130-3137.
Tietze, L. F., et al., “Improved Synthesis of (E)-3-Alkoxy- and (E)-3- Phenoxyacryloyl Chlorides”,Synthesis, (Nov. 1993), 1079-1080.

Affiliated with

Also associated with

Rating

Therapeutic amides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic amides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic amides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3602904