Therapeutic amides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S562000, C514S567000, C514S568000, C549S075000, C549S078000, C562S426000, C562S433000

Reexamination Certificate

active

07985767

ABSTRACT:
Compounds of the formulaare disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

REFERENCES:
patent: 4166452 (1979-09-01), Generales
patent: 4225609 (1980-09-01), Cragoe
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen
patent: 4386031 (1983-05-01), Hilboll et al.
patent: 6437146 (2002-08-01), Hattori
patent: 6710072 (2004-03-01), Burk
patent: 7468360 (2008-12-01), Old et al.
patent: WO 2006/020767 (2006-02-01), None
Stella, Valentino J, Expert Opinion of Therapeutic Patents, Prodrugs as therapeutics, 2004 14(3): 277-280.
Wolff et al. (Burger's Medicinal Chemistry, 5th Ed., vol. 1, pp. 975-977, 1994).
Testa, Bernard, Biochemical Pharmacology, Prodrug Research: futile or fertile? 68 (2004) 2097-2106.
Ettmayer, Peter, Medicinal Chemistry, Lessons Learned from Marketed and Investigational Prodrugs, 47(10) (2004) 2394-2404.
Patani, George A. Bioisosterism: A rational approach in drug design. Chem. Rev. 96 (1996) 3147-3176.
Anderson, KE; et al.: Oxadiazoles as Bioisosteric Transformations of Carboxylic Functionalities. II. Eur J. Med. Chem. 1996, 31, 417-425.
Cameron, Kimberly; et al.: Discovery of Highly Selective EP4 Receptor Agonists That Stimulate New Bone Formation and Restore Bone Mass in Ovariectomized Rats. Bioorg. Med. Chem. Lett. 2006, 16, 1799-1802.
Chourasia, MK; et al.: Pharmaceutical Approaches to Colon Targeted Drug Delivery Systems. J Pharm Pharmaceut Sci 6(1): 33-66, 2003.
Drysdale et al.: Rationally designed “dipeptoid” analogs of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist (CI-988). J. Med. Chem. 1992, 35, 2573-2581.
Francis A. Carey, Organic Chemistry, New York: McGraw-Hill Book Company 1987, p. 63.
Hans, Wei; et al.: Investigation of Glycine β-ketoamide HCV NS3 Protease Inhibitors: Effect of Carboxylic Acid Isosteres. Bioorganic & Medicinal Chemistry Letters 15 (2005) 3487-3490.
Hartwig, J.F.: “Palladium-Catalyzed Amination of Aryl Halides and Related Reactions” In Handbook of Organopalladium Chemistry for Organic Synthesis; Negishi, E.I.; Wiley-Interscience: New York, 2002; vol. 1, p. 1051.
Jiang, Lei and Buchwald, Stephen: Metal-Catalyzed Cross-Coupling Reactions, 2nded.: de Meijere, A., Diederich, F., Eds.; Wiley-VCH: Weinheim, Germany, 2004, p. 699.
Klapars, Artis; et al.: A General and Efficient Copper Catalyst for the Amidation of Aryl Halides. J. Am. Chem. Soc. 2002, 124, 7421-7428.
U.S. Appl. No. 11/009,298, filed Dec. 10, 2004, Donde.
U.S. Appl. No. 11/553,143, filed Oct. 26, 2006, Donde.
Kohara et al.: Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres J. Med. Chem. 1996, 39, 5228-5235.
Orlek et al.: Comparison of Azabicyclic Esters and Oxadiazoles as Ligands for the Muscarinic Receptor. J. Med. Chem. 1991, 34, 2726-2735.
Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pa., 16thEd. 1980.
Shareef, Ajmal; et al.: Colonic Drug Delivery: An Updated Review. AAPS PharmSci 2003; 5(2) Article 17.
Shen, Qilong; et al.: Palladium-Catalyzed Coupling of Ammonia and Lithium Amide with Aryl Halides. J. Am. Chem. Soc. 2006, 128, 10028-10029.
Shih, et al.: Synthesis and Biological Activity of Acyclic Analogs of 5,10-dideaza-5,6,7,8-tetrahydrofolic Acid. J. Med. Chem. 1992, 35, 1109-1116.
Silverman, Richard B.: “Bioisosteres are substituents or groups that have chemical or physical similarities, and which produce broadly similar biological properties.” The Organic Chemistry of Drug Design and Drug Action, 2nded. Amsterdam: Elsevier Academic Press, 2004, p. 29.
Yin, Jingjun; et al.: Palladium-Catalyzed Intermolecular Coupling of Aryl Halides and Amides.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic amides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic amides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic amides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2661452

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.