Therapeutic amides

Details Therapeutic amides Therapeutic amides

1993-09-24

1995-01-17

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514534, 514613, 514624, 514628, 558414, 560107, 560255, 564123, 564189, 564190, 564202, A61K 31165, C07C23516

Patent

active

053825985

ABSTRACT:
Amides having formula I: ##STR1## wherein E, X, R.sup.2 and R.sup.3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolyzable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.

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R. Bayles et al., "The Smiles rearrangement of 2-aryloxy-2-methylpropanamides. Synthesis of N-aryl-2-hydroxy-2-methylpropanamides" Synthesis. (1977), 31-33.
G. Edwards et al., "Structure-activity relationships of potassium channel openers", Trends in Pharmacological Sciences. (1990), 11, 417-422.

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