Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-07-21
2009-08-11
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S277000, C514S336000, C514S340000, C514S359000, C514S365000, C514S369000, C514S371000, C514S374000, C514S376000, C514S383000, C514S385000, C548S530000, C548S300100, C548S316400, C548S317100, C548S321100, C548S146000, C548S182000, C548S183000, C548S185000, C548S131000, C548S125000, C548S250000, C548S262200, C548S266200, C548S266400, C548S190000, C548S191000, C548S356100, C548S364100, C546S268100, C546S276400, C546S278400, C546S278700, C546S112000, C546S152000, C546S165000, C546S166000, C546S181000, C544S
Reexamination Certificate
active
07572816
ABSTRACT:
The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R5and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals
REFERENCES:
patent: 2004/0122059 (2004-06-01), Cantorna et al.
“Cellular Processes.” Retrieved via the Internet [Jul. 15, 2008] URL: http://en.wikipedia.org/wiki/Category:Cellular—processes.
“Cancer.” Retrieved via the Internet [Jul. 15, 2008] URL: http://www.nlm.nih.gov/medlineplus/cancer.html.
Golub et al. Science (1999), vol. 286 521-537.
Lala et al. Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Sarshar Sepehr
Tse Bruno
Auspex Pharmaceuticals, Inc.
Bennett Dennis A.
Saeed Kamal A
Sertic Michael
Shterengarts Samantha L
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