Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1981-09-18
1983-05-31
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
A61K 3170
Patent
active
043860788
ABSTRACT:
Disclosed is a method for substantially maintaining glycerophospholipid production by cells and for suppressing consequent free fatty acid proliferation in said cells wherein injury or disease has caused normal glycerophospholipid production of said cells to become retarded. Such method comprises presenting said cell with CDP-ethanolamine, CDP-N-methylethanolamine, CDP-N,N-dimethylethanolamine, mixtures thereof or mixtures of these compounds with CDP-choline . Injuries or diseases to which the method has applicability include ischemia, heart disease, stroke, and spinal cord injury. The CDP-compounds may be administered either before or after the onset of the injury or disease.
REFERENCES:
M. Martinet et al., "Effects of Cytidine-5 Diphosphocholine on Norepinephrine, Dopamine and Serotonin Synthesis in Various Regions of the Rat Brain (1)".
M. Martinet et al., "Interaction of CDP-Choline with Synaptosomal Transport of Biogenic Amines and Their Precursors in Vitro and in Vivo in the Rat Corpus Striatum," Experientia 34, 1197-1199, (1978).
M. Rigoulet et al., "Unilateral Brain Injury in the Rabbit; Reversible and Irreversible Damage of the Membranal ATPases", J. Neurochem 27, 535-541, (1979).
F. Cohadon et al., "Oedeme Cerebral Vasogemique", Nouvelle Press Medicale, 8 1589-1591, (1979).
F. Boismare et al., "Action of Cytidine Diphosphocholine on Functional and Hemodynamic Effects of Cerebral Ischemia in Cats", Pharmacology 17 15-20, (1978).
Chemical Abstracts, 91, 17553c, (1979).
Manaka, et al., Experientia 30, 179-180, (1974).
Dabrowiecki Zbigniew M.
Dorman Robert V.
Horrocks Lloyd A.
Hazel Blondel
The Ohio State University Research Foundation
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