Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-03-08
2005-03-08
Jones, Dameron L. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
C514S167000, C514S739000, C424S009100
Reexamination Certificate
active
06864247
ABSTRACT:
An object of the present invention is to provide pharmaceutical compositions for inhibiting mesangial cell proliferation or mesangial matrix production without causing hypercalcemia.According to the present invention, therapeutic agents for glomerulosclerosis containing 1α,3β-dihydroxy-20α-(3-hydroxy-3-methylbutyloxy)-9,10-seco-5,7,10 (19)-pregnatriene as an active ingredient are provided.
REFERENCES:
patent: 6506741 (2003-01-01), Doi
patent: 9-110717 (1997-04-01), None
patent: 9-169648 (1997-06-01), None
patent: 02-028114 (1998-04-01), None
patent: 10-306024 (1998-11-01), None
English translation of abstract of JP 02-028114, 1998, p. 1.
Junko Abe, et al, “Prevention of Immunological Disorders in MRL/1 Mice by a New Synthetic Analogue of Vitamin D3: 22-Oxa-1α,25-Dihydroxyvitamin D3” J. Nutr. Sci. Vitaminol., vol. 36, 1990, pp. 21-31.
Yue J. Liu and Boon S. Ooi, “Responses of Mesangial Cells of Autoimmune Mice to Cyokines” Journal of Immunology, vol. 151, No. 4, Aug. 15, 1993, pp. 2247-2251.
Abe et al, “A Vitamin D Analog Regulates Mesangial Cell Smooth Muscle Phenotypes in a Transforming Growth Factor-Beta Type II Receptor-Mediated Manner, ”The Journal of Biological Chemistry, vol. 274, No. 99, Jul. 23, 1999, pp. 20874-20878, United States.
Browdy and Neimark , P.L.L.C.
Jones Dameron L.
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