Therapeutic agents as cytokine antagonists and agonists

Details Therapeutic agents as cytokine antagonists and agonists Therapeutic agents as cytokine antagonists and agonists

2006-12-19

2006-12-19

Murphy, Joseph (Department: 1647)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S139100, C514S002600, C514S023000, C435S007100, C530S389100

Reissue Patent

active

RE039433

ABSTRACT:
A therapeutic agent capable of of binding to the F′-G′ loop of domain 4 of the commoncChain of the receptor for GM-CSF, IL-3, and IL-5. The amino acid Tyr421which is located in the F′-G′ loop is critical in the high affinity binding and stimulation of function of GM-CSF, IL-3 and IL-5 to the commoncchain of the receptors. Other receptors for cytokines also show hydrophobic amino acids in analogous positions and it is probable that they too play a pivotal role in binding of respective cytokines to them and in modulating function. Agents capable of binding to the F′-G′ loops are suggested and should be of therapeutic value.

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