Therapeutic agents and methods of use thereof for the...

Details Therapeutic agents and methods of use thereof for the... Therapeutic agents and methods of use thereof for the...

2005-07-19

2005-07-19

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S016700, C514S475000, C514S478000, C514S588000

Reexamination Certificate

active

06919307

ABSTRACT:
The present invention provides methods of treating a parasitic infection, a lymphoid malignancy or an autoimmune disorder in a subject by administering to the subject a therapeutically effective amount of an angiogenesis inhibitor compound comprising a MetAP-2 inhibitory core coupled to a peptide.

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Griffith EC, et al. “Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2.”Proc Natl Acad Sci U S A.Dec. 22, 1998;95(26):15183-8.
Zhang et al. “Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria andLeishmaniasis.” J. Biomed Sci.2002;9:34-40.

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