Therapeutic agents and corresponding treatments

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S511000, C514S553000, C564S080000

Reexamination Certificate

active

06919376

ABSTRACT:
Compositions and methods of using an MT103 family member, wherein MT103 is the chemical N,N-dicyclohexyl-(1S)-isoborneol-10-sulfonamide. Uses of the compositions include cancer therapy, antibacterials, antifungals, induction of apoptosis, and hormonal antagonists.

REFERENCES:
patent: 6290929 (2001-09-01), Camden
patent: 6352844 (2002-03-01), Maurer et al.
SIGMA, Biochemicals, Organic Compounds, Diagnostic Reagents, p. 340.
Gerona-Navarro et al., General Approach for the Stereocontrolled Construction of the Beta-Lactam Ring in Amino Acid-Derived 4-Alkyl-4-carboxy-2-azetidinones, Journal of Organic Chemistry, 67, pp. 3953-3956, published on web Apr. 26, 2002.
Hernanz et al., Synthesis and Configuration Assignment of (R) and (S)-2-bromohexadecanoic Acids, Tetrahedron: Asymmetry, vol. 6, No. 9 pp 2291-2298 (1995).
Oppolzer et al., Asymmetric Diels-Alder Reactions: Facile Preparation and Structure of Sulfonamido-Isobornyl Acrylates, Tetrahedron Letters, vol. 25, No. 51 pp 5885-5888 (1984).
Cativiela et al., “New Approaches to the Asymmetric Synthesis of ∝-Methylphenylalanie”Tetrahedron Letters, vol. 5, No. 2, pp. 261-268. (1994).
R. Ohme; H. Preuschhof. Liebigs Ann. Chem., “Hydrazine und Azoverbindungen aus Diamiden der Schwefelsaure”,Justus Liebigs Annalen der Chemie, vol. 713, pp. 74-86.
Bermann, Manfred; Van Wazer, John R. Synthesis, “Preparation of N,N′-Dimethyl-and N,N′-Diethylsulfamid”,Synthesis, vol. 10, pp. 576-577.
Oppolzer, W., “Chiral auxiliary conferring excellent diastereodifferentiation in reactions of O-enoyl and enolate derivatives,”Tetrahedron, vol. 43, No. 9, pp. 1969-2004.
Oppolzer, W. and Moretti, R. “Enantioselective systheses of α-amino acids from 10-sulfonamido-isobornyl esters and di-t-butyl azodiacarboxylate”,Tetrahedron, vol. 44, No. 17, pp. 5541-5552.
Gray, G. and Wickstrom, E., “Evaluation of Anchorage-Independt Proliferation in Tumorigenic Cells Using the Redox Dye alamarBlue™”,Biotechniques, vol. 21, No. 5, pp. 780-782.
J. Gálvez, R. García-Domenech, C. de Gregorio Alapont, J.V. de Julián-Ortiz, and L. Popa, “Pharmacological distribution diagrams: A tool for de novo drug design”,Journal of Molecular Graphics, vol. 14, pp. 272-276.
Boyd, M., MD, Ph.D., “The NCI In Vitro Anticancer Drug Discovery Screen”Anticancer Drug Development Guide, Preclinical Screening, Clinical Trials, and Approval, B. Teicher Humana Press, Inc. pp. 23-42.
Dewynter, G., Abdaoui, M., Toupet, L. and Montero, J., “SulfonylBis-N-Oxazolidinone (SBO): A New Versatile Dielectrophile with Sequential Reactivity”,Tetrehedron Letters, vol. 38, No. 50, pp. 8691-8694.
Gong, B.; Zheng, C.; Skrzpczak-Jankun, E.; Yan, Y.; Zhang, J.; “A Robus Two-Dimensional Hydrogen-Bonded Network: The Sulfamide Moiety as a New Builidng Block for the Design of Molecular Solids”,J. Am. Chem. Soc., vol. 120, No. 43, pp. 11194-11195.
Gong, B.; Zheng, C.; Zeng, H.; Zhu, J., “Polar Assembly of N,N′-Bis(4-substituted benzyl)sulfamides”,J. Am. Chem. Soc., vol. 121, pp. 9766-9767.
Nuckolls C., Hof, F.; Martin, T.; Rebek J. Jr.; “Chiral Microenvironments in Self-Assembled Capsules”,J. Am. Chem. Soc., vol. 121, pp. 10281-10285.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic agents and corresponding treatments does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic agents and corresponding treatments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic agents and corresponding treatments will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3389251

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.