Therapeutic agents

Details Therapeutic agents Therapeutic agents

1992-03-24

1993-08-31

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424474, 424475, 424476, 424477, 424478, 424479, 424480, 424481, 424482, 424484, 424485, 424486, 424487, 424488, 514570, 514937, 514938, 71DIG1, A61K 3174

Patent

active

052407128

ABSTRACT:
A high content of 2-(4-isobutylphenyl)propionic acid is achieved in a pharmaceutical composition by solidifying molten 2-(4-isobutylphenyl)propionic acid to provide a unit dose composition. The composition may be prepared by heating the 2-(4-isobutylphenyl)-propionic acid until molten, optionally mixing with pharmaceutically acceptable excipients, forming into a unit dosage presentation and allowing the composition to solidify. Preferably the composition contains greater than 80% ibuprofen or S(+)-ibuprofen and is filled into a hard gelatin capsule.

REFERENCES:
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 4545992 (1985-10-01), Kamishita
patent: 4690823 (1987-09-01), Lohner
patent: 4786495 (1988-11-01), Bird et al.
patent: 4793999 (1988-12-01), Seth
"Preparation and Dissolution Characteristics of Solid Dispersions of Ibuprofen . . . " by P. Mura et al., Il Farmaco, Jun. 1987, vol. XLII, No. 6, pp. 150-155.
"Phase Equilibria, Crystallinity and Dissolution Rates . . . " by Mura P. et al., Il Farmaco, Jun. 1987, vol. XLII, No. 6, pp. 157-164.

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