Therapeutic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564305, 544403, 546346, 546348, 548578, 514242, 514277, 514359, 514408, A01N 3302

Patent

active

047466804

ABSTRACT:
Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

REFERENCES:
patent: 4443449 (1984-04-01), Jeffery et al.
patent: 4522828 (1985-06-01), Jeffery et al.
Chem. Abs., 87, 23236s--Synthesis of Novel Cyclic & Acyclic Sulphamides.
Chem. Abs., 85, 32678y--Aminoesters of 1-(Alpha-Naphthyl) Cycloalkane-1-Carboxylic Acids and 1-(Alpha-Naphthyl) Cycloalkane-1-Methyl Guanidines in Russian and copy of English translation attached.
Arya and Shenoy--Synthesis of New Heterocycles, Indian Journal of Chemistry, 14B, 766-769 (1976).
Armyanskii Khimichesdii Zhurnal, 29, No. 2, 194-199 (1976).
"Neurotransmitters and Drugs", by Kruk and Pycock, Croom Helm London, p. 149.
Nieforth and Cohen, "Central Nervous System Stimulants", Chapter 13 of the book entitled Principles of Medicinal Chemistry, by Foye, second edition, Lea & Febiger, 1981, Phil., pp. 303-316.
Israel Journal of Chemistry 13 No. 2 (1975), pp. 125-136, A. Kalir, "1-Phenylcycloalkylamine Derivatives III".
"1-Phenylcycloalkylamine Derivatives. II, Synthesis and Pharmacological Activity", A. Kalir, (1969), pp. 473-477, of vol. 12, J. Med. Chem.
Kalir, et al., 1-Phenylcycloakylamine Derivatives I, Israel Journal of Chemistry 5 (1967), pp. 223-229.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1058717

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.