Therapeutic agent for the treatment of septicaemia its...

Details Therapeutic agent for the treatment of septicaemia its... Therapeutic agent for the treatment of septicaemia its...

2005-09-27

2005-09-27

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S008100, C514S014800, C514S015800, C514S021800, C530S350000, C435S069500, C435S069700, C435S235100, C435S320100, C424S009100

Reexamination Certificate

active

06949512

ABSTRACT:
A therapeutic agent for the treatment of septicemia, its preparation and use, with application in the pharmaceutical industry and medicine. This therapeutic agent contains essential element, the lipopolysaccharide binding protein (LBP). Also disclosed are LBP variants, mutants and hybrid proteins. Murine or rabbit LBP may also be used, besides human LBP.

REFERENCES:
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patent: WO-9425476 (1994-11-01), None
patent: WO 95/08560 (1995-03-01), None
patent: WO-9508560 (1995-03-01), None
Lamping, et al., Immune consequences Trauma, Shoc Sepsis, Int. Congr. 4th (1997) 15-19.
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Lamping et al., J Clin. Invest. 101, 2065-2071 (1998).
Schumann et al., Science 249 (4975) 1429-1431 (1990).
Lengacher et al. Reactivity of murine and human recombinant LPS binding protein (LBP) within LPS and gram negative bacteria. J. Inflammation 47, 165-172 (1995/1996).
Lengachev et al., J. Inflammation 47, 165-172 (1995/1996).
Zweigner et al., Blood 96 (13), 3800-3808 (Dec. 2001).

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