Therapeutic agent for substance dependence

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S468000

Reexamination Certificate

active

07825158

ABSTRACT:
The present invention provides a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior based on craving for addictive substances such as stimulant substances, opioids, barbiturate type anesthetics, hallucinogens, cocaine, hemp, cannabis, alcohol, or volatile organic solvents. (−)-1-(Benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is useful as a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior associated with craving for addictive substances.

REFERENCES:
patent: 6391914 (2002-05-01), Knoll et al.
patent: WO 01/77074 (2001-10-01), None
Shimadzu, “Pharmacological studies with endogenous enhancer substances: β-phenylethylamine, tryptamine, and their synthetic derivatives”Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2004, 28(3), 421-427.
Bartzokis, “Selegiline Effects on Cocaine-Induced Changes in Medial Temporal Lobe Metabolism and Subjective Ratings of Euphoria”, Neuropsychopharmacology, vol. 20 (6), 1999, p. 582-590.

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