Therapeutic agent for neuropathic pain

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07851485

ABSTRACT:
Disclosed is a therapeutic agent for neuropathic pain having an excellent therapeutic effect on neuropathic pain which is a intractable disease. More specifically, disclosed are a therapeutic agent for neuropathic pain which comprises a peripheral benzodiazepine receptor antagonist (particularly PK 11195) as the active ingredient; a pharmaceutical composition for the treatment of neuropathic pain which comprises a peripheral benzodiazepine receptor antagonist as the active ingredient; a method for the treatment of neuropathic pain using a peripheral benzodiazepine receptor antagonist; and others.

REFERENCES:
patent: 2008/0194620 (2008-08-01), Besne et al.
patent: 2002-516279 (2002-06-01), None
patent: WO 99/49316 (1999-09-01), None
patent: WO 99/61024 (1999-12-01), None
patent: WO 00/37086 (2000-06-01), None
Supplementary European Search Report dated Dec. 7, 2009, in corresponding EP 06732484.2, 8 pages.
Galiegue et al., “The Peripheral Benzodiazepine Receptor: A Promising Therapeutic Drug Target,” Current Medicinal Chemistry, 2003, 10:1563-1572.
Hempenstall et al., “Current treatment options in neuropathic pain,” Current Opinion in Investigational Drugs, 2002, 3(3):441-448.
Kontinen et al., “Effects of midazolam in the spinal nerve ligation model of neuropathic pain in rats,” Pain, 2000, 85:425-431.
Dalbo et al., “Antinociceptive Effects of Peripheral Benzodiazepine Receptors,” Pharmacology, 2004, 70(4):188-94.
Database BIOSIS on STN, BIOSIS (Philadelphia, PA, USA), DN: PREV200000147669 & Sloan, J.W. et al., Effect of chronic diazepam (DZ) treatment, and flumazenil (FLU)—and PK 11195 (PK)-induced withdrawal on the pain threshold in femal rats, Society for Neuroscience Abstracts, 1999, vol. 25, No. 1-2, p. 1948 (abstract, two pages).
Karchewski et al., “Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons,” European Journal of Neuroscience, 2004, 20(3):671-83.
Rady et al., “Confluence of Antianalgesic Action of Diverse Agents through Brain Interleukin1βin Mice,” J. Pharmacol. Exp. Ther., 2001, 299(2):659-665.
Xiao et al., “Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain,” Proc. Natl. Acad. Sci., Jun. 11, 2002, 99(12):8360-8365.

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