Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-10-26
1997-02-11
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3155
Patent
active
056021232
ABSTRACT:
A therapeutic agent for myocardial ischemic damages or reperfusion injuries which contains, as an active ingredient, a compound of the following formula (1), an acid addition salt thereof, or a hydrate thereof: ##STR1## wherein R.sup.1 to R.sup.6 are lower alkoxy groups and A and A' are lower alkylene groups; a method for treating those disorders which uses the above compound; and use of the compound in the manufacture of such a therapeutic agent. The therapeutic agent has an excellent action of recovering lowered heart functions caused by myocardial ischemia-reflow, and have low toxicity.
REFERENCES:
patent: 5389630 (1995-02-01), Sato et al.
Japanese Journal of Pharmacology, vol. 67, No. S1, p. 121P, Mar. 1995, A. N. Hoque, et al., "Cardioprotective Effect of K-7259, A New Delazep Derivative, in the Ischemic-Reperfused Isolated Working Rat Hearts".
Japanese Journal of Pharmacolgy, vol. 59, No. S1, p. 256P, 1992, Y. Yamauchi, et al., "Neuroprotective Effects of K-7259 Against Cerebral Anoxia and Ischemia".
The Kurume Medical Journal, vol. 41, No. 3, pp. 123-130, 1994, M. Tsurusaki, et al., "Effects of K-7259 on Neuronal Activity and Synaptic Transmission in the Rat Dorsolateral Septal Nucleus".
Martindale, The Extra Pharmacopoeia, p. 1019, 1993, J. E. F. Reynolds, "Dilazep Hydrochloride".
Arneimittelforschung/Drug Research, vol. 35, No. 12, pp. 1802-1804, 1985, S. Sugiyama, et al., "The Effects of Dilazep on Reperfusion Arrhythmias".
STN File Supplier: Medline AN-90284804, 1990, Y. Yamauchi, et al., "Effect of Dilazep Dihydrochloride on Ischemia and Reperfusion-Induced Cerebral Injury in Spontaneously Hypertensive Rats" (Abstract Only).
K. Ichihara et al, Journal of Cardiovascular Pharmacology, "Effects of Diltiazem and Propranolol on Irreversibility of Ischemic Cardiac Function and Metabolism in the Isolated Perfused Rat Heart", vol. 5, pp. 745-751, (1983).
Abiko Yasushi
Hara Akiyoshi
Hashizume Hiroko
Kawagoe Junichi
Yamauchi Yoichi
Henley III Raymond
Kowa Co. Ltd.
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