Therapeutic agent for inflammatory bowel disease

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07820686

ABSTRACT:
The invention is directed to a method of treating an inflammatory bowel disease such as ulcerative colitis or Crohn's disease, which comprises administering an effective amount of the therapeutic agent 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione, or a pharmaceutically acceptable salt thereof, to a patient with inflammatory bowel disease.

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Zou et al., Journal of Tongji Medical University, 21(4), (2001), pp. 308-309.
Stephan R. Targan, et al., “A short-term study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease”, The New England Journal of Medicine, Oct. 9, 1997, vol. 337, No. 15, pp. 1029-1035.
Paul Rutgeerts, et al., “Efficacy and Safety of Retreatment With Anti-Tumor Necrosis Factor Antibody (Infliximab) to Maintain Remission in Crohn's Disease”, Gastroenterology, 1999, vol. 117, No. 4, pp. 761-769.

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