Therapeutic agent for corneal disorders

Details Therapeutic agent for corneal disorders Therapeutic agent for corneal disorders

1993-02-25

1995-07-18

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

530351, A61K 3820, A61K 3800, C07K 1454

Patent

active

054339448

ABSTRACT:
A method for the healing of wounds caused by corneal injury as the result of, for example, corneal ulcer, corneal epithelial defect, keratitis, xerophthalmia, which comprises locally administering to a patient in need thereof an effective wound healing amount of interleukin-6, either alone, or in combination with one or more pharmaceutically acceptable ophthalmic excipients.

REFERENCES:
patent: 5300292 (1994-04-01), Ulich
Nishida, T. et al.; Ophthalmology 92:213-216, 1985.
Nishida, et al., Arch Ophthamol. vol. 101, Jul. 1985 pp. 1046-1051.
Droses et al., Annals of Rheumatic Diseases, vol. 45, pp. 732-735, 1986.
Behrens-Baumann, Acta Ophthalmalogica, vol. 70, pp. 690-692, 1992.
Portnoy et al., Cornea, vol. 10, No. 1, 1991, pp. 690-692.
Portnoy et al., Cornea vol. 10, No. 1, pp. 17-20, 1991.
Huang, A. J. Investigative Ophthalmology and Visual Science, vol. 32, No. 3, pp. 633-639, 1991.
Raqge et al., British Journal of Ophthalmology, vol. 74 pp. 381-382, 1990.
Klotz et al., Investigative Ophthalmology and Visual Science, vol. 30, No.6, Jun. 1989, pp. 1069-1074.
Archives of Ophthalmology, vol. 110, No. 9, Sep. 1992, pp. 1292-1294, Nishida et al., Interleukin 6 Facilitates Corneal Epithelial Wound Closure in Vitro.
The Journal of Investigative Dermatology, vol. 94, No. 6, Jun. 1990, pp. 2S-6S, Sehgal, P. B. et al., Interleukin-6: Molecular Pathophysiology.

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