Therapeutic agent

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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26050116, A61K 944, C07C10110

Patent

active

045017271

ABSTRACT:
The N-methyl-D-glucamine salt of (+)-2-(2-fluoro-4-biphenylyl)propionic acid, which is a novel compound with analgesic, anti-inflammatory and antipyretic properties and which is useful for treating inflammatory conditions including rheumatic disorders and as an analgesic. Pharmaceutical compositions containing the novel salt are also described. Also described are methods for preparing the novel salt by direct salification in an aqueous or non-aqueous medium, for example isopropanol, aqueous tetrahydrofuran, bis(methoxyethyl) ether and 4-methyl-1,3-dioxolan-2-one. Isopropanol is especially preferred.

REFERENCES:
patent: 3860624 (1975-01-01), Diamond
patent: 3891761 (1975-06-01), Sherlock
patent: 3903134 (1975-09-01), Diamond
patent: 3932499 (1976-01-01), Adams et al.
patent: 3985788 (1976-10-01), Diamond
patent: 3987197 (1976-10-01), Engel et al.
patent: 4209638 (1980-06-01), Nicholson et al.
Chemical Abstract, vol. 98, #59892a, Antiinflammatory Formulations and Synthesis of Phenylacetate Derivatives, Ciba-Geigy.

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