Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1982-12-03
1985-02-26
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
26050116, A61K 944, C07C10110
Patent
active
045017271
ABSTRACT:
The N-methyl-D-glucamine salt of (+)-2-(2-fluoro-4-biphenylyl)propionic acid, which is a novel compound with analgesic, anti-inflammatory and antipyretic properties and which is useful for treating inflammatory conditions including rheumatic disorders and as an analgesic. Pharmaceutical compositions containing the novel salt are also described. Also described are methods for preparing the novel salt by direct salification in an aqueous or non-aqueous medium, for example isopropanol, aqueous tetrahydrofuran, bis(methoxyethyl) ether and 4-methyl-1,3-dioxolan-2-one. Isopropanol is especially preferred.
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patent: 4209638 (1980-06-01), Nicholson et al.
Chemical Abstract, vol. 98, #59892a, Antiinflammatory Formulations and Synthesis of Phenylacetate Derivatives, Ciba-Geigy.
Armitage Bernard J.
Donaldson Margaret L.
Covington Raymond
Hollrah Glennon H.
Hueschen Gordon W.
The Boots Company PLC
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