Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-23
1999-10-05
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3155
Patent
active
059624590
ABSTRACT:
Uridine is a therapeutic agent active as a growth promoter for treatment of neuron degenerative diseases deriving from pathological ageing or selective destruction, in particular Uridine shows the same biological effects as NGF, when added at low doses to the culture medium, so that uridine may replace NGF as therapeutic agent in neural diseases and it may be also associated with other growth factors that allow differentiation of neurons, or with anti-cancer and anti-virus drugs that cause neuron damage. In addition uridine shows important trophic properties on various types of cultured cells, stimulating cell reproduction when used at rather high dose levels.
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S.A. Keilbaugh et al., "Anti-Human Immunodeficiency Virus Type 1 Therapy and Peripheral Neuropathy: Prevention of 2',3'-Dideoxycytidine Toxicity in PC12 Cells, a Neuronal Model, by Uridine and Pyruvate", Molec. Pharmacology, vol. 44, No. 4, pp. 702-706, Oct., 1993.
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Chemical Abstracts AN 1986:418201, Agnati et al, "Intravenous uridine treatment antagonizes hypoglycemia-induced reduction in brain somatostatin-like immunoreactivity", Acta Physiol. Scand., 126(4), 525-31, Jan. 1986.
Chemical Abstracts AN 1992:242332, Mervis et al, "Exongenous nerve growth factor reverses age-related structural changes in neocortical neurons in the ageing rat", Ann. N.Y. Acad. Sci., 95-101, Jan. 1991.
Materazzi, deceased Mario
Piazza Cinzia
Politi Vincenzo
MacMillan Keith D.
Polifarma S.p.A.
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