Theophyllinylmethyldioxolane derivatives, methods for their prep

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424253, 544118, 544267, 544271, A61K 2700, A61K 3152, C07D47300

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active

043783597

ABSTRACT:
Compounds of the following general formula ##STR1## wherein: X and Y are different from each other and represent --CH.sub.2 -- or an oxygen atom; R represents a radical selected from hydroxy, bromo, acetoxy, pyrrolidino, morpholino, piperazino and piperazino substituted at the position 4 by a carbethoxy, benzyl, phenyl, halophenyl, methoxyphenyl or trifluoromethylphenyl group, or when X is --CH.sub.2 -- and Y is an oxygen atom, R may represent also chloro; methods for their preparation; pharmaceutical compositions containing them. The compounds possess a remarkable antitussive activity.

REFERENCES:
patent: 2761861 (1956-09-01), Doebel et al.
patent: 2840559 (1958-06-01), Krantz, Jr. et al.
patent: 3734911 (1973-05-01), Bestian
Chem. Abstracts 61: 662b.

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