Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-04-06
1983-03-29
Love, Ethel G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424253, 544118, 544267, 544271, A61K 2700, A61K 3152, C07D47300
Patent
active
043783597
ABSTRACT:
Compounds of the following general formula ##STR1## wherein: X and Y are different from each other and represent --CH.sub.2 -- or an oxygen atom; R represents a radical selected from hydroxy, bromo, acetoxy, pyrrolidino, morpholino, piperazino and piperazino substituted at the position 4 by a carbethoxy, benzyl, phenyl, halophenyl, methoxyphenyl or trifluoromethylphenyl group, or when X is --CH.sub.2 -- and Y is an oxygen atom, R may represent also chloro; methods for their preparation; pharmaceutical compositions containing them. The compounds possess a remarkable antitussive activity.
REFERENCES:
patent: 2761861 (1956-09-01), Doebel et al.
patent: 2840559 (1958-06-01), Krantz, Jr. et al.
patent: 3734911 (1973-05-01), Bestian
Chem. Abstracts 61: 662b.
Chiodoni Ugo
Franzone Jose S.
Spinelli Silvano
Istituto Biologico Chemioterapico "ABC" S.p.A.
Love Ethel G.
Unibios S.p.A
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