Theophyllinemethyldithiolan and theophyllinemethyldithianyl deri

Details Theophyllinemethyldithiolan and theophyllinemethyldithianyl deri Theophyllinemethyldithiolan and theophyllinemethyldithianyl deri

1987-12-24

1989-09-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544271, 544272, A61K 3152, C07D47308

Patent

active

048681865

ABSTRACT:
New derivatives of theophylline are described, which have the general formula: ##STR1## in which R is selected from the group consisting of 2'-(1'-oxy-1', 3'-dithiolanyl), 2'-(1', 3'-dithiolanyl) and 2'-(1',3'-dithianyl), possibly substituted in position 4'. The derivatives have high antibronchospastic, antitussive and mucolytic activities.

REFERENCES:
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patent: 4109006 (1978-08-01), Johnson et al.
patent: 4289776 (1981-09-01), Mohler et al.
patent: 4309553 (1982-01-01), Shepherd
patent: 4378359 (1983-03-01), Chiodoni et al.
patent: 4640929 (1987-02-01), Mitsudera et al.
patent: 4755517 (1988-07-01), Bruns et al.
Fieser, J. Am. Chem. Soc., vol. 76, pp. 1945-1947 (04/05/54).

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