Theophylline test

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Sample mechanical transport means in or for automated...

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23230B, 23929, 252408, G01N 2178, G01N 3352

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active

043259081

ABSTRACT:
Theophylline concentrations in body fluids can be determined by a color reaction. The theophylline is converted to theophyllidine by reaction with an alkali such as sodium or potassium hydroxide at an elevated temperature and, after neutralization of the alkali with an organic acid, the theophyllidine formed is coupled with a chromogen to yield a color whose depth is proportional to the theophylline concentration in the body fluid being tested. The improved procedure utilizes a solid alkali for the heating step and a non-corrosive acid for the neutralization. An improved chromogen yields a bright, relatively stable purple color.

REFERENCES:
patent: 2418033 (1947-03-01), Kamlet
patent: 3449081 (1969-06-01), Hughes
patent: 3585004 (1971-06-01), Mast
patent: 3955926 (1976-05-01), Fischer
Truitt et al., J. of Pharmacology & Experimental Therapeutics 91, (1947), pp. 185-189.
Truitt, Jr. et al., "The Quantitative Estimation of Theophylline in Blood", Chem. Abstr., vol. 42, No. 630h, 1948.
Gerhard et al., "Indirect Plasma-Theophylline Monitoring in Asthmatic Children by Det. of Theophylline Conc. in Saliva", Chem. Abstr., vol. 81, 1974, No. 130743c.

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