Theophylline derivatives

Details Theophylline derivatives Theophylline derivatives

1983-09-01

1986-07-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544269, C07D47310, A61K 3152

Patent

active

045994145

ABSTRACT:
Derivatives of theophylline substituted at the 7 position with various substituents containing a homopiperazine nucleus. The compounds can be prepared reacting theophylline or reactive intermediate containing same with a homopiperazine compound. The compounds exhibit antihistaminic activity and vasodilating activity.

REFERENCES:
patent: 3459753 (1969-08-01), Boltze et al.
patent: 4493837 (1985-01-01), Sugimoto et al.
Kohda et al., Chemical Abstracts, vol. 77, 1972, 88551d.
Albert, Heterocyclic Chemistry, 1968, title page and p. 43.
Geiszler et al., Chemical Abstracts, vol 71, 1969, 24739q.
Kono, et al., Chemical Abstracts, vol. 74, 1971, 53865v.
Brookes et al., Journal of the Chemical Society, "The Chemotherapy of Filariasis", 1957 Part III, title page and pp. 3165-3172.
Poppelsdorf et al., Journal of Organic Chemistry, "A Novel Synthesis of Homopiperazine and Its Monomethyl Derivatives," vol. 26, Jan. 1961, pp. 131-134.
Sommers et al., Journal of the American Chemical Society, "Homopiperazines Related to Chlorocyclizine", vol. 76, Oct.-Dec. 1954, title page and p. 5805.

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