Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1979-01-11
1980-10-28
Schain, Howard E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
260112R, 260112B, 260121, 424 85, 424 88, 435 7, 525420, C07G 700, C07G 702
Patent
active
042308054
ABSTRACT:
Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for production of antibodies which specifically recognize theophylline as distinct from structurally similar analogs such as caffeine. Enzyme conjugates are provided which find use for measuring the amount of theophylline in a sample suspected of containing theophylline. A method is provided employing the reagents for the determination of theophylline.
REFERENCES:
patent: 3875011 (1975-04-01), Rubenstein et al.
patent: 4053459 (1977-10-01), Christenson
patent: 4067774 (1978-01-01), Rubenstein et al.
patent: 4156081 (1979-05-01), Singh et al.
Research Communications in Chemical Pathology & Pharmacology, vol. 13, No. 3, Mar. 1976, Cook et al.
Hu Mae W.
Singh Prithipal
Rowland Bertram I.
Schain Howard E.
Syva Company
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