The Alz-50 monoclonal antibody and diagnostic assay for alzheime

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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436528, 436531, 436 84, 435 7021, 435326, 435 71, 435 721, 435 792, 5303881, G01N 3353

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active

058113100

ABSTRACT:
The invention relates to an antigen associated with Alzheimer's disease and to antibodies specific for said antigen. This invention further relates to methods for diagnosing Alzheimer's disease utilizing assays containing Alzheimer's associated antigen, antibodies specific for said antigen and samples from an individual suspected of having Alzheimer's disease.

REFERENCES:
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patent: 4666829 (1987-05-01), Glenner
Wolozin et al., Ann. Neurol 22:521-526, 1987.
Ksiezak-Reding et al, J. Biol. Chem 263(7):7943-7947, 1988.
Dickson et al, Acta Neuopathologica, 84:596-605 (1992).
Joachim et al, Journal of Neuropathology and Experimental Neuropathol. 46(6):611-622, Nov. 1987.
Davies et al, Society for Neuroscience Abstracts, 19:1636, Abstract 670.3.
Vincent et al, Society for Neuroscience Abstracts, 19:1636, Abstract 670.4.
Harlow et al, Antibodies: A Laboratory Manual, .COPYRGT.1988 by Cold Spring Harber Press pp. 139-243.

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