Th1 inducing natural adjuvant for heterologous antigens

Details Th1 inducing natural adjuvant for heterologous antigens Th1 inducing natural adjuvant for heterologous antigens

2005-08-30

2005-08-30

Minnifield, Nita (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S184100, C424S185100, C424S191100, C424S193100, C424S194100, C424S197110, C424S201100, C424S203100, C424S234100, C424S275100, C424S450000, C424S823000, C424S824000, C424S825000, C424S826000, C424S828000, C424S829000, C424S269100, C424S248100, C435S041000, C435S042000, C435S069100, C435S069700, C435S252100, C514S002600, C514S008100

Reexamination Certificate

active

06936263

ABSTRACT:
The present invention relates to the use of the major OprI lipoprotein ofPseudomonas aeruginosato elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI—antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.

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